Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Wei, Yanhong ; Dai, Jiayin ; Liu, Min ; Wang, Jianshe ; Xu, Muqi ; Zha, Jinmiao ; Wang, Zijian |
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
 |
| 出版日期 | 2007-11 |
| 卷号 | 26期号:11页码:2440-2447 |
| 关键词 | perfluorooctanoic acid rare minnow estrogen-responsive gene gonad endocrine disruptors |
| 英文摘要 | Perfluorooctanoic acid (PFOA) is an important perfluorinated compound (PFC) with various applications and has been widely disseminated in the environment, wildlife, and humans. The present study investigated the effects of waterborne PFOA on the expression of hepatic estrogen-responsive genes, vitellogenin (VTG), and estrogen receptor P (ER beta) and on the gonadal development in a freshwater rare minnow (Gobiocypris rarus). The mRNA levels of VTG and ER beta were determined using reverse transcription polymerase chain reaction (RT-PCR) techniques, and VTG protein levels were identified using enzyme-linked immunosorbent assay. A significant increase of VTG expression in the livers of both mature males and females was observed after 14 and 28 d of exposure to 3, 10, and 30 mg/L PFOA, indicating that PFOA could induce VTG synthesis. The expression of ERP increased significantly in livers of both mature males and females after a 14-d exposure, although no difference was observed after a 28-d exposure. The development of oocytes in testes exposed to PFOA also provided evidence of estrogenic activity in males. The ovaries of PFOA-exposed females underwent degeneration, as reported in other fish species exposed to environmental estrogens. This preliminary study indicates that PFOA can disturb the activity of estrogen in mature male rare minnows by inducing hepatic estrogen-responsive genes, VTG and ER beta, and barrier female reproduction. |
| WOS记录号 | WOS:000250260700024 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22559]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Wei, Yanhong,Dai, Jiayin,Liu, Min,et al. Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus)[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2007,26(11):2440-2447. |
| APA | Wei, Yanhong.,Dai, Jiayin.,Liu, Min.,Wang, Jianshe.,Xu, Muqi.,...&Wang, Zijian.(2007).Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus).ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,26(11),2440-2447. |
| MLA | Wei, Yanhong,et al."Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus)".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 26.11(2007):2440-2447. |
入库方式： OAI收割
来源：生态环境研究中心
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