Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)
文献类型：期刊论文
| 作者 | Sun, Liwei ; Zha, Jinmiao ; Spear, Philip A. ; Wang, Zijian |
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2007-07 |
| 卷号 | 24期号:1页码:23-29 |
| 关键词 | tamoxifen selective estrogen-receptor modulator (SERM) early life stage reproduction transgenerational effects |
| 英文摘要 | Tamoxifen is widely used in the treatment of breast cancer and can enter the aquatic environment in municipal wastewater. To evaluate potential effects on embryonic development of Japanese medaka, fertilized eggs were exposed to tamoxifen at 1-625 mu g/l for 14 days. Adverse effects on hatchability and time to hatching only occurred at 125 and 625 mu g/l. Reproductive effects were assessed by exposing adults for 21 days to the same dose range. At all concentrations tested, tamoxifen significantly increased plasma vitellogenin levels in males in a dose-dependent manner. Fecundity and fertility were detrimentally affected at 625 mu g/l. Additionally, F1 eggs were removed from tamoxifen-contaminated water to evaluate transgenerational effects. Hatchability was affected at 625 mu g/l but no morphological deformities were observed. A significant dose-dependent increase in the proportion of genotypic males occurred at all concentrations greater than 5 mu g/l. (C) 2007 Elsevier B.V. All rights reserved. |
| WOS记录号 | WOS:000246837100005 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22601]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, Liwei,Zha, Jinmiao,Spear, Philip A.,et al. Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2007,24(1):23-29. |
| APA | Sun, Liwei,Zha, Jinmiao,Spear, Philip A.,&Wang, Zijian.(2007).Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes).ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,24(1),23-29. |
| MLA | Sun, Liwei,et al."Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes)".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 24.1(2007):23-29. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。