Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults
文献类型：期刊论文
| 作者 | Sun, Liwei ; Zha, Jinmiao ; Spear, Philip A. ; Wang, Zijian |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
 |
| 出版日期 | 2007-05 |
| 卷号 | 145期号:4页码:533-541 |
| 关键词 | endocrine disrupting chemical sex ratio transgenerational effects vitellogenin estrogen teleost |
| 英文摘要 | Letrozole is a synthetic aromatase inhibitor and interferes in the committed step in the synthesis of endogenous estrogens from androgens. To evaluate potential effects on the early life stages of Japanese medaka, larvae and fertilized eggs were exposed to letrozole for 96 h and 14 days, respectively. No larvae died and no adverse effects were found on embryonic development at concentrations up to 3125 mu g/L. Reproductive effects were assessed by exposing adults to 1, 5, 25, 125 and. 625 mu g/L letrozole for 21 days. A dose-dependent decrease in fecundity (> 25 mu g/L) and fertility (> 5 mu g/ L) accompanied by histological changes suggested the inhibition of oocyte growth and possibly maturation. At 625 mu g/L, the fish ceased spawning during the last week of exposure. Letrozole (> 5 mu g/L) reduced plasma vitellogenin levels in females in a dose-dependent manner. Transgenerational effects were evaluated by removing freshly-laid F I eggs from letrozole-contaminated water and raising them to 15 days post-hatching in control water. Hatchability and time to hatching were detrimentally affected (> 5 mu g/L), but no morphological deformities were observed. Furthermore, a dose-dependent increase in the proportion of genotypic F1 males was found (> 5 mu g/L). (c) 2007 Elsevier Inc. All rights reserved. |
| WOS记录号 | WOS:000246935300005 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/22606]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, Liwei,Zha, Jinmiao,Spear, Philip A.,et al. Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2007,145(4):533-541. |
| APA | Sun, Liwei,Zha, Jinmiao,Spear, Philip A.,&Wang, Zijian.(2007).Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,145(4),533-541. |
| MLA | Sun, Liwei,et al."Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 145.4(2007):533-541. |
入库方式： OAI收割
来源：生态环境研究中心
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