Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)
文献类型：期刊论文
| 作者 | Zhao, Yang1,2,3; Liu, Weisheng1,2; Li, Qi4; Yang, Qin1,2; Chai, Wenbo3; Zeng, Mengjing1,2; Li, Renhui3; Peng, Yiyuan1,2 |
| 刊名 | BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 94期号:3页码:376-381 |
| 关键词 | Bioassay CMQ Growth inhibition Microcystis Photosystem |
| ISSN号 | 0007-4861 |
| 通讯作者 | Peng, YY (reprint author), Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China. |
| 英文摘要 | Quinazoline derivatives have wide biological activities and therapeutic properties, implying their potential for development and application on a large scale. In the present study, 2-(4-chlorophenyl)-4-(4-methoxyphenyl) quinazoline (CMQ), was selected to examine its effect on unicellular cyanobacteria, Microcystis aeruginosa by evaluating growth, physiological and molecular responses. Growth was inhibited by CMQ, with a 96 h EC50 of 1.93 +/- A 0.19 mg L-1. The up-regulated expression of prx was shown, reflecting that oxidative stress might be a toxic factor of CMQ. At higher concentrations of CMQ, the quantum yields of Y(II) and Y(NPQ) in photosystem II decreased seriously and Y(NO) increased sharply, and psbA gene encoding for D1 protein was over-expressed. These results demonstrated that high concentrations of CMQ had different inhibitory targets associated with photosystem electron transport and with sites beyond the electron transport chain, leading to severe toxicity. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Environmental Sciences ; Toxicology |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology |
| 关键词[WOS] | PHOTOSYSTEM-II ; CHLOROPHYLL FLUORESCENCE ; GENE-EXPRESSION ; GROWTH ; TOXICITY ; INHIBITION ; MECHANISM ; STRESS ; AGENTS ; PCR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000349960900019 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/25770]  |
| 专题 | 水生生物研究所_藻类生物学及应用研究中心_期刊论文 |
| 作者单位 | 1.Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China 2.Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Key Lab Algal Biol, Wuhan 430072, Peoples R China 4.Wuhan Foreign Language Sch, Wuhan 430022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yang,Liu, Weisheng,Li, Qi,et al. Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)[J]. BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,2015,94(3):376-381. |
| APA | Zhao, Yang.,Liu, Weisheng.,Li, Qi.,Yang, Qin.,Chai, Wenbo.,...&Peng, Yiyuan.(2015).Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria).BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY,94(3),376-381. |
| MLA | Zhao, Yang,et al."Multiparameter-Based Bioassay of 2-(4-Chlorophenyl)-4-(4-methoxyphenyl) Quinazoline, a Newly-Synthesized Quinazoline Derivative, Toward Microcystis aeruginosa HAB5100 (Cyanobacteria)".BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 94.3(2015):376-381. |
入库方式： OAI收割
来源：水生生物研究所
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