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Biological insights from 108 schizophrenia-associated genetic loci

文献类型:期刊论文

AuthorRipke, Stephan1,2; Neale, Benjamin M.1,2,3,4; Corvin, Aiden5; Walters, James T. R.6; Farh, Kai-How1; Holmans, Peter A.6,7; Lee, Phil1,2,4; Bulik-Sullivan, Brendan1,2; Collier, David A.8,9; Huang, Hailiang1,3
SourceNATURE
Issued Date2014-07-24
Volume511Issue:7510Pages:421-+
ISSN0028-0836
English AbstractSchizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.
Indexed TypeSCI
Language英语
WOS IDWOS:000339335700037
源URL[http://ir.psych.ac.cn/handle/311026/14207]  
Collection心理研究所_健康与遗传心理学研究室
Affiliation1.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
2.Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA
3.Broad Inst MIT & Harvard, Med & Populat Genet Program, Cambridge, MA 02142 USA
4.Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA
5.Univ Ireland Trinity Coll, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin 8, Ireland
6.Cardiff Univ, Sch Med, MRC Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff CF24 4HQ, S Glam, Wales
7.Cardiff Univ, Natl Ctr Mental Hlth, Cardiff CF24 4HQ, S Glam, Wales
8.Eli Lilly & Co Ltd, Erl Wood Manor, Windlesham GU20 6PH, Surrey, England
9.Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London SE5 8AF, England
10.Tech Univ Denmark, Dept Syst Biol, Ctr Biol Sequence Anal, DK-2800 Lyngby, Denmark
Recommended Citation
GB/T 7714
Ripke, Stephan,Neale, Benjamin M.,Corvin, Aiden,et al. Biological insights from 108 schizophrenia-associated genetic loci[J]. NATURE,2014,511(7510):421-+.
APA Ripke, Stephan.,Neale, Benjamin M..,Corvin, Aiden.,Walters, James T. R..,Farh, Kai-How.,...&Wellcome Trust Case-Control Consor.(2014).Biological insights from 108 schizophrenia-associated genetic loci.NATURE,511(7510),421-+.
MLA Ripke, Stephan,et al."Biological insights from 108 schizophrenia-associated genetic loci".NATURE 511.7510(2014):421-+.

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来源:心理研究所

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