Insula-amygdala functional connectivity is correlated with habituation to repeated negative images
文献类型：期刊论文
| 作者 | Denny, Bryan T.1; Fan, Jin1,2,3; Liu, Xun4 ; Guerreri, Stephanie1; Mayson, Sarah Jo1; Rimsky, Liza1; New, Antonia S.1,5; Siever, Larry J.1,5; Koenigsberg, Harold W.1,5
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| 刊名 | SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
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| 出版日期 | 2014-11-01 |
| 卷号 | 9期号:11页码:1660-1667 |
| 关键词 | habituation emotion functional connectivity insula amygdala |
| ISSN号 | 1749-5016 |
| 英文摘要 | Behavioral habituation during repeated exposure to aversive stimuli is an adaptive process. However, the way in which changes in self-reported emotional experience are related to the neural mechanisms supporting habituation remains unclear. We probed these mechanisms by repeatedly presenting negative images to healthy adult participants and recording behavioral and neural responses using functional magnetic resonance imaging. We were particularly interested in investigating patterns of activity in insula, given its significant role in affective integration, and in amygdala, given its association with appraisal of aversive stimuli and its frequent coactivation with insula. We found significant habituation behaviorally along with decreases in amygdala, occipital cortex and ventral prefrontal cortex (PFC) activity with repeated presentation, whereas bilateral posterior insula, dorsolateral PFC and precuneus showed increased activation. Posterior insula activation during image presentation was correlated with greater negative affect ratings for novel presentations of negative images. Further, repeated negative image presentation was associated with increased functional connectivity between left posterior insula and amygdala, and increasing insula-amygdala functional connectivity was correlated with increasing behavioral habituation. These results suggest that habituation is subserved in part by insula-amygdala connectivity and involves a change in the activity of bottom-up affective networks. |
| 收录类别 | SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345846800003 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13486]  |
| 专题 | 心理研究所_认知与发展心理学研究室 |
| 作者单位 | 1.Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA 2.Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA 3.CUNY Queens Coll, Dept Psychol, New York, NY 11367 USA 4.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 5.James J Peters VA Med Ctr, Bronx, NY 10468 USA |
| 推荐引用方式 GB/T 7714 | Denny, Bryan T.,Fan, Jin,Liu, Xun,et al. Insula-amygdala functional connectivity is correlated with habituation to repeated negative images[J]. SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,2014,9(11):1660-1667. |
| APA | Denny, Bryan T..,Fan, Jin.,Liu, Xun.,Guerreri, Stephanie.,Mayson, Sarah Jo.,...&Koenigsberg, Harold W..(2014).Insula-amygdala functional connectivity is correlated with habituation to repeated negative images.SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE,9(11),1660-1667. |
| MLA | Denny, Bryan T.,et al."Insula-amygdala functional connectivity is correlated with habituation to repeated negative images".SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE 9.11(2014):1660-1667. |
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来源：心理研究所
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