Identification of neurons responsible for feeding behavior in the Drosophila brain
文献类型：期刊论文
| 作者 | Sun Fei1,2; Wang YiJin1; Zhou YanQiong1,3; Van Swinderen, Bruno3; Gong ZheFeng1,4; Liu Li1,5
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| 刊名 | SCIENCE CHINA-LIFE SCIENCES
 |
| 出版日期 | 2014-04-01 |
| 卷号 | 57期号:4页码:391-402 |
| ISSN号 | 1674-7305 |
| 关键词 | feeding behavior sugar-sensing neurons SOG CAFE assay proboscis extension response (PER) |
| 英文摘要 | Drosophila melanogaster feeds mainly on rotten fruits, which contain many kinds of sugar. Thus, the sense of sweet taste has evolved to serve as a dominant regulator and driver of feeding behavior. Although several sugar receptors have been described, it remains poorly understood how the sensory input is transformed into an appetitive behavior. Here, we used a neural silencing approach to screen brain circuits, and identified neurons labeled by three Ga14 lines that modulate Drosophila feeding behavior. These three Ga14 lines labeled neurons mainly in the suboesophageal ganglia (SOG), which is considered to be the fly's primary taste center. When we blocked the activity of these neurons, flies decreased their sugar consumption significantly. In contrast, activation of these neurons resulted in enhanced feeding behavior and increased food consumption not only towards sugar, but to an array of food sources. Moreover, upon neuronal activation, the flies demonstrated feeding behavior even in the absence of food, which suggests that neuronal activation can replace food as a stimulus for feeding behavior. These findings indicate that these Ga14-labeled neurons, which function downstream of sensory neurons and regulate feeding behavior towards different food sources is necessary in Drosophila feeding control. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000334559600006 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13439]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100039, Peoples R China 3.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 4.Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China 5.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun Fei,Wang YiJin,Zhou YanQiong,et al. Identification of neurons responsible for feeding behavior in the Drosophila brain[J]. SCIENCE CHINA-LIFE SCIENCES,2014,57(4):391-402. |
| APA | Sun Fei,Wang YiJin,Zhou YanQiong,Van Swinderen, Bruno,Gong ZheFeng,&Liu Li.(2014).Identification of neurons responsible for feeding behavior in the Drosophila brain.SCIENCE CHINA-LIFE SCIENCES,57(4),391-402. |
| MLA | Sun Fei,et al."Identification of neurons responsible for feeding behavior in the Drosophila brain".SCIENCE CHINA-LIFE SCIENCES 57.4(2014):391-402. |
入库方式： OAI收割
来源：心理研究所
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