Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe
文献类型：期刊论文
| 作者 | Li, Rui1,2 ; Zhu, Xinyi1; Yin, Shufei1; Niu, Yanan1,2; Zheng, Zhiwei1; Huang, Xin1; Wang, Baoxi1; Li, Juan1,2
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| 刊名 | FRONTIERS IN AGING NEUROSCIENCE
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| 出版日期 | 2014-03-10 |
| 卷号 | 6期号:0页码:39 |
| 关键词 | intervention plasticity aging fMRI functional connectivity |
| ISSN号 | 1663-4365 |
| 英文摘要 | The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging. The disconnection between them is suggested to be an important cause of cognitive decline in normal aging. Here, using multimodal intervention training, we investigated the functional plasticity in resting-state connectivity of these two regions in older adults. The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain. Results showed that the intervention selectively affected resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe. Moreover, the strength of resting-state functional connectivity between these regions correlated with individual cognitive performance. Our results suggest that multimodal intervention could postpone the effects of aging and improve the function of the regions that are most heavily influenced by aging, as well as play an important role in preserving the brain and cognition during old age. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000332607600001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13479]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Ctr Aging Psychol, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Rui,Zhu, Xinyi,Yin, Shufei,et al. Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe[J]. FRONTIERS IN AGING NEUROSCIENCE,2014,6(0):39. |
| APA | Li, Rui.,Zhu, Xinyi.,Yin, Shufei.,Niu, Yanan.,Zheng, Zhiwei.,...&Li, Juan.(2014).Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe.FRONTIERS IN AGING NEUROSCIENCE,6(0),39. |
| MLA | Li, Rui,et al."Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe".FRONTIERS IN AGING NEUROSCIENCE 6.0(2014):39. |
入库方式： OAI收割
来源：心理研究所
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