Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction
文献类型：期刊论文
| 作者 | Shen, Fang1 ; Duan, Ying1,2; Jin, Shubo1,2; Sui, Nan1
|
| 刊名 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE
 |
| 出版日期 | 2014-09-23 |
| 卷号 | 8期号:0页码:333 |
| 关键词 | tree shrews morphine locomotor activities conditioned place preference/aversion (CPP/CPA) self-administration |
| ISSN号 | 1662-5153 |
| 英文摘要 | Tree shrews represent a suitable animal model to study the pathogenesis of human diseases as they are phylogenetically close to primates and have a well-developed central nervous system that possesses many homologies with primates. Therefore, in our study, we investigated whether tree shrews can be used to explore the addictive behaviors induced by morphine. Firstly, to investigate the psychoactive effect of morphine on tree shrews' behavior, the number of jumping and shuttling, which represent the vertical and horizontal locomotor activity respectively, was examined following the injection of different dosage of morphine. Our results showed intramuscular OM) injection of morphine (5 or 10 mg/kg) significantly increased the locomotor activity of tree shrews 30-60 min post injection Then, using the conditioned place preference/aversion (CPP/CPA) paradigm, we found morphine-conditioned tree shrews exhibited place preference in the morphine-paired chamber on the test day. In addition, naloxone-precipitated withdrawal induced place aversion in the chronic morphine-dependent tree shrews. We evaluated the craving for morphine drinking by assessing the break point that reflects the maximum effort animals will expend to get the drug. Our data showed the break point was significantly increased when compared to the baseline on the 1st, 7th and 14th day after the abstinence. Moreover, in the intravenous morphine self-administration experiment, tree shrews conditioned with morphine responded on the active lever significantly more frequently than on the inactive lever after training. These results suggest that tree shrew may be a potential candidate for study the addictive behaviors and the underling neurological mechanisms. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342032700001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13483]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Fang,Duan, Ying,Jin, Shubo,et al. Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2014,8(0):333. |
| APA | Shen, Fang,Duan, Ying,Jin, Shubo,&Sui, Nan.(2014).Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,8(0),333. |
| MLA | Shen, Fang,et al."Varied behavioral responses induced by morphine in the tree shrew: a possible model for human opiate addiction".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8.0(2014):333. |
入库方式： OAI收割
来源：心理研究所
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