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Genetic linkage analysis in the age of whole-genome sequencing
文献类型：期刊论文
| 作者 | Ott, Jurg1,2; Wang, Jing1 ; Leal, Suzanne M.3
|
| 刊名 | NATURE REVIEWS GENETICS
 |
| 出版日期 | 2015-05-01 |
| 卷号 | 16期号:5页码:275-284 |
| ISSN号 | 1471-0056 |
| 英文摘要 | For many years, linkage analysis was the primary tool used for the genetic mapping of Mendelian and complex traits with familial aggregation. Linkage analysis was largely supplanted by the wide adoption of genome-wide association studies (GWASs). However, with the recent increased use of whole-genome sequencing (WGS), linkage analysis is again emerging as an important and powerful analysis method for the identification of genes involved in disease aetiology, often in conjunction with WGS filtering approaches. Here, we review the principles of linkage analysis and provide practical guidelines for carrying out linkage studies using WGS data. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353164800009 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13523]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 3.Baylor Coll Med, Dept Human & Mol Genet, Ctr Stat Genet, Houston, TX 77030 USA |
| 推荐引用方式 GB/T 7714 | Ott, Jurg,Wang, Jing,Leal, Suzanne M.. Genetic linkage analysis in the age of whole-genome sequencing[J]. NATURE REVIEWS GENETICS,2015,16(5):275-284. |
| APA | Ott, Jurg,Wang, Jing,&Leal, Suzanne M..(2015).Genetic linkage analysis in the age of whole-genome sequencing.NATURE REVIEWS GENETICS,16(5),275-284. |
| MLA | Ott, Jurg,et al."Genetic linkage analysis in the age of whole-genome sequencing".NATURE REVIEWS GENETICS 16.5(2015):275-284. |
入库方式： OAI收割
来源：心理研究所
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