gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila
文献类型：期刊论文
| 作者 | Liu, Jiangqu1,2; Gong, Zhefeng1; Liu, Li1,3
|
| 刊名 | JOURNAL OF NEUROCHEMISTRY
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 130期号:3页码:408-418 |
| 关键词 | GABA GABA(A) receptor Ggt-1 Glutamate green-light avoidance |
| ISSN号 | 0022-3042 |
| 英文摘要 | Drosophila larvae innately show light avoidance behavior. Compared with robust blue-light avoidance, larvae exhibit relatively weaker green-light responses. In our previous screening for genes involved in larval light avoidance, compared with control w(1118) larvae, larvae with gamma-glutamyl transpeptidase 1 (Ggt-1) knockdown or Ggt-1 mutation were found to exhibit higher percentage of green-light avoidance which was mediated by Rhodopsin6 (Rh6) photoreceptors. However, their responses to blue light did not change significantly. By adjusting the expression level of Ggt-1 in different tissues, we found that Ggt-1 in malpighian tubules was both necessary and sufficient for green-light avoidance. Our results showed that glutamate levels were lower in Ggt-1 null mutants compared with controls. Feeding Ggt-1 null mutants glutamate can normalize green-light avoidance, indicating that high glutamate concentrations suppressed larval green-light avoidance. However, rather than directly, glutamate affected green-light avoidance indirectly through GABA, the level of which was also lower in Ggt-1 mutants compared with controls. Mutants in glutamate decarboxylase 1, which encodes GABA synthase, and knockdown lines of the GABA(A) receptor, both exhibit elevated levels of green-light avoidance. Thus, our results elucidate the neurobiological mechanisms mediating green-light avoidance, which was inhibited in wild-type larvae. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000339479200008 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13740]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jiangqu,Gong, Zhefeng,Liu, Li. gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila[J]. JOURNAL OF NEUROCHEMISTRY,2014,130(3):408-418. |
| APA | Liu, Jiangqu,Gong, Zhefeng,&Liu, Li.(2014).gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila.JOURNAL OF NEUROCHEMISTRY,130(3),408-418. |
| MLA | Liu, Jiangqu,et al."gamma-glutamyl transpeptidase 1 specifically suppresses green-light avoidance via GABA(A) receptors in Drosophila".JOURNAL OF NEUROCHEMISTRY 130.3(2014):408-418. |
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来源：心理研究所
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