MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1
文献类型：期刊论文
| 作者 | Liu, Kaili1,2,3; Liu, Ying1,2 ; Mo, Weichuan1,3; Qiu, Rong1; Wang, Xiumei1,2; Wu, Jane Y.1,4; He, Rongqiao1,3,5
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| 刊名 | NUCLEIC ACIDS RESEARCH
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| 出版日期 | 2011-04-01 |
| 卷号 | 39期号:7页码:2869-2879 |
| ISSN号 | 0305-1048 |
| 英文摘要 | MicroRNAs (miRNAs) are involved in the fine control of cell proliferation and differentiation during the development of the nervous system. MiR-124, a neural specific miRNA, is expressed from the beginning of eye development in Xenopus, and has been shown to repress cell proliferation in the optic cup, however, its role at earlier developmental stages is unclear. Here, we show that this miRNA exerts a different role in cell proliferation at the optic vesicle stage, the stage which precedes optic cup formation. We show that miR-124 is both necessary and sufficient to promote cell proliferation and repress neurogenesis at the optic vesicle stage, playing an anti-neural role. Loss of miR-124 upregulates expression of neural markers NCAM, N-tubulin while gain of miR-124 downregulates these genes. Furthermore, miR-124 interacts with a conserved miR-124 binding site in the 3'-UTR of NeuroD1 and negatively regulates expression of the proneural marker NeuroD1, a bHLH transcription factor for neuronal differentiation. The miR-124-induced effect on cell proliferation can be antagonized by NeuroD1. These results reveal a novel regulatory role of miR-124 in neural development and uncover a previously unknown interaction between NeuroD1 and miR-124. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000289628400041 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13779]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Key Lab Noncoding RNA, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Northwestern Univ, Feinberg Sch Med, Lurie Comprehens Canc Ctr, Ctr Genet Med,Dept Neurol, Chicago, IL 60611 USA 5.Chinese Acad Sci, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Kaili,Liu, Ying,Mo, Weichuan,et al. MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1[J]. NUCLEIC ACIDS RESEARCH,2011,39(7):2869-2879. |
| APA | Liu, Kaili.,Liu, Ying.,Mo, Weichuan.,Qiu, Rong.,Wang, Xiumei.,...&He, Rongqiao.(2011).MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1.NUCLEIC ACIDS RESEARCH,39(7),2869-2879. |
| MLA | Liu, Kaili,et al."MiR-124 regulates early neurogenesis in the optic vesicle and forebrain, targeting NeuroD1".NUCLEIC ACIDS RESEARCH 39.7(2011):2869-2879. |
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来源：心理研究所
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