Peritraumatic startle response predicts the vulnerability to develop PTSD-like behaviors in rats: a model for peritraumatic dissociation
文献类型：期刊论文
| 作者 | Dong, Xinwen ; Li, Yonghui
|
| 刊名 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE
 |
| 出版日期 | 2014-01-28 |
| 卷号 | 8期号:0页码:14 |
| 关键词 | post-traumatic stress disorder startle peritraumatic dissociation vulnerability rat models |
| ISSN号 | 1662-5153 |
| 英文摘要 | Peritraumatic dissociation, a state characterized by alteration in perception and reduced awareness of surroundings, is considered to be a risk factor for the development of post-traumatic stress disorder (PTSD). However, the predictive ability of peritraumatic dissociation is questioned for the inconsistent results in different time points of assessment. The startle reflex is an objective behavioral measurement of defensive response to abrupt and intense sensory stimulus of surroundings, with potentials to be used as an assessment on the dissociative status in both humans and rodents. The present study examined the predictive effect of acoustic startle response (ASR) in different time points around the traumatic event in an animal model of PTSD. The PTSD-like symptoms, including hyperarousal, avoidance, and contextual fear, were assessed 2-3 weeks post-trauma. The results showed that (1) the startle amplitude attenuated immediate after intense footshock in almost half of the stress animals, and (2) the attenuated startle responses at 1 h but not 24 h after stress predicted the development of severe PTSD-like symptoms. These data indicate that the startle alteration at the immediate period after trauma, including 1 h, is more important in PTSD prediction than 24 h after trauma. Our study also suggests that the startle attenuation immediate after intense stress may serve as an objective measurement of peritraumatic dissociation in rats. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330542200001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14125]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Xinwen,Li, Yonghui. Peritraumatic startle response predicts the vulnerability to develop PTSD-like behaviors in rats: a model for peritraumatic dissociation[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2014,8(0):14. |
| APA | Dong, Xinwen,&Li, Yonghui.(2014).Peritraumatic startle response predicts the vulnerability to develop PTSD-like behaviors in rats: a model for peritraumatic dissociation.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,8(0),14. |
| MLA | Dong, Xinwen,et al."Peritraumatic startle response predicts the vulnerability to develop PTSD-like behaviors in rats: a model for peritraumatic dissociation".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 8.0(2014):14. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。