Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment
文献类型：期刊论文
| 作者 | Shao, Shuang1; Li, Man1; Du, Wei1; Shao, Feng1; Wang, Weiwen2
|
| 刊名 | BRAIN RESEARCH
 |
| 出版日期 | 2014-11-17 |
| 卷号 | 1589期号:1589页码:105-111 |
| 关键词 | Adolescence MK-801 Social isolation Galanthamine Prepulse inhibition |
| ISSN号 | 0006-8993 |
| 英文摘要 | Adolescence is a critical period for neurodevelopment. MK-801 treatment and social isolation are important animal models for various neurodevelopmental disorders. Dysfunctions in the central cholinergic system are involved in creating the cognitive deficits observed in neurological diseases. In the present study, we aimed to investigate whether the acetylcholinesterase inhibitor galanthamine could reverse pre-cognitive prepulse inhibition (PPI) deficits and spatial learning deficits of adult rats in the Morris water maze. We induced these effects using either adolescent MK-801 treatment or social isolation from postnatal day (PND) 38-51. Our results showed that both adolescent social isolation and MK-801 treatment impaired PPI in adult rats, but neither had an effect on spatial learning. Furthermore, galanthamine injections over 7 days significantly enhanced PPI of normal rats and improved PPI disruption induced by adolescent pharmacological and rearing interventions. The results suggest that acetylcholinesterase inhibitors, such as galanthamine, might have the potential to improve pre-cognition in neurodevelopmental diseases by improving auditory sensory gating. (C) 2014 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345732600011 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14128]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Peking Univ, Dept Psychol, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Shuang,Li, Man,Du, Wei,et al. Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment[J]. BRAIN RESEARCH,2014,1589(1589):105-111. |
| APA | Shao, Shuang,Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2014).Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment.BRAIN RESEARCH,1589(1589),105-111. |
| MLA | Shao, Shuang,et al."Galanthamine, an acetylcholine inhibitor, prevents prepulse inhibition deficits induced by adolescent social isolation or MK-801 treatment".BRAIN RESEARCH 1589.1589(2014):105-111. |
入库方式： OAI收割
来源：心理研究所
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