Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats
文献类型：期刊论文
| 作者 | Ji, Weifeng1; Huang, Haiying2; Chao, Ji3; Lu, Wuchao1; Guo, Jianyou4
|
| 刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
 |
| 出版日期 | 2014 |
| 卷号 | 2014期号:0页码:679259 |
| ISSN号 | 1741-427X |
| 英文摘要 | Objective. The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats. STZ-induced diabetic rats were administered orally with AbS. Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters. After 6 weeks of treatments, all animals were sacrificed to study various biochemical parameters. Treatment with AbS 80 mg/kg in diabetic animals showed significant increase in body weight, pain threshold, and paw withdrawal threshold and significant decrease in serum glucose, LPO and NO level, Na-K-ATPase level, and TNF-alpha. and IL-1 beta. level as compared to vehicle treated diabetic animals in dose and time dependent manner. AbS can offer pain relief in PDN. This may be of potential benefit in clinical practice for the management of diabetic neuropathy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000330444000001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14140]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Med Univ, Dept Orthoped, Chinese Orthoped & Traumatol Res Inst, Affiliated Hosp Zhejiang 1, Hangzhou 310006, Zhejiang, Peoples R China 2.Henan Univ Tradit Chinese Med, Sch Pharm, Zhengzhou 450046, Peoples R China 3.Fujian Med Univ, Sch Basic Med, Fuzhou 350108, Peoples R China 4.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Weifeng,Huang, Haiying,Chao, Ji,et al. Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014,2014(0):679259. |
| APA | Ji, Weifeng,Huang, Haiying,Chao, Ji,Lu, Wuchao,&Guo, Jianyou.(2014).Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2014(0),679259. |
| MLA | Ji, Weifeng,et al."Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014.0(2014):679259. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。