Anti-inflammatory Cytokines and Depression
文献类型：期刊论文
| 作者 | Xu Yue1,2; Lin Wen-Juan1
|
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2014-11-01 |
| 卷号 | 41期号:11页码:1099-1108 |
| 关键词 | depression cytokines anti-inflammatory cytokines anti-inflammation antidepressant |
| ISSN号 | 1000-3282 |
| 英文摘要 | In recent years, the cytokine hypothesis of depression has received considerable research attention, providing insights on the mechanism study and the therapeutic treatment of depressive disorders. Two classes of cytokines, pro-inflammatory cytokines and anti-inflammatory cytokines, are proven to be associated with depression. In this review, the focus is on the research of anti-inflammatory cytokines, which are believed to have a key role in alleviating depression-related symptoms. Anti-inflammatory cytokines, such as interleukin-10, interleukin-1 receptor antagonist, interleukin-4, interleukin-13, transforming growth factor-beta, and adiponectin, show decreased concentrations during depressive episodes. Anti-inflammatory cytokines participate in the regulation mechanism of depression through antagonizing pro-inflammatory cytokines and interacting with MAPK signaling, neurotransmitters, and glucocorticoids. Various kinds of antidepressants can lead to an increased secretion of anti-inflammatory cytokines, which might be the action mechanism of antidepressants. Overall, accumulating evidences from the literature demonstrate positive prospects of using anti-inflammatory cytokines as a therapeutic alternative to treat depression. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000345267500002 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14222]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 101408, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu Yue,Lin Wen-Juan. Anti-inflammatory Cytokines and Depression[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2014,41(11):1099-1108. |
| APA | Xu Yue,&Lin Wen-Juan.(2014).Anti-inflammatory Cytokines and Depression.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,41(11),1099-1108. |
| MLA | Xu Yue,et al."Anti-inflammatory Cytokines and Depression".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 41.11(2014):1099-1108. |
入库方式： OAI收割
来源：心理研究所
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