Integration of animal behaviors under stresses with different time courses
文献类型：期刊论文
| 作者 | Zheng, Lun1 ; Zheng, Xigeng2
|
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2014-08-01 |
| 卷号 | 9期号:15页码:1464-1473 |
| 关键词 | nerve regeneration brain injury depression stress resistance susceptible to depression chronic unpredictable stress forced swim dopamine nucleus accumbens NSFC grant neural regeneration |
| ISSN号 | 1673-5374 |
| 英文摘要 | We used animal models of "forced swim stress" and "chronic unpredictable stress", and tried to reveal whether a passive coping style of high flotation behavior in forced swim stress predicts anhedonia behavior after chronic unpredictable stress, and whether the dopamine system regulates floating and anhedonia behaviors. Our results confirmed that depression-prone rats use "floating behavior" as a coping strategy in forced swim stress and more readily suffer from anhedonia during chronic unpredictable stress. Intraperitoneal injection or nucleus accumbens microinjection of the dopamine 2/3 receptor subtype agonist ropinirole reduced floating behaviors in depression-prone animals, but increased sucrose preference in rats showing anhedonia. These data indicate that floating behavior is a defensive mode that is preferred by susceptible individuals under conditions of acute stress. Simultaneously, these animals more readily experienced anhedonia under long-term stress; that is, they were more readily affected by depression. Our results suggest that dopamine 2/3 receptor subtypes in the nucleus accumbens play an important role in floating behaviors and anhedonia. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000342650400011 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14228]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Lun,Zheng, Xigeng. Integration of animal behaviors under stresses with different time courses[J]. NEURAL REGENERATION RESEARCH,2014,9(15):1464-1473. |
| APA | Zheng, Lun,&Zheng, Xigeng.(2014).Integration of animal behaviors under stresses with different time courses.NEURAL REGENERATION RESEARCH,9(15),1464-1473. |
| MLA | Zheng, Lun,et al."Integration of animal behaviors under stresses with different time courses".NEURAL REGENERATION RESEARCH 9.15(2014):1464-1473. |
入库方式： OAI收割
来源：心理研究所
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