TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors
文献类型：期刊论文
| 作者 | Cao, Chengqi1,2; Wang, Li1 ; Wang, Richu1,2; Qing, Yulan1,2; Zhang, Jianxin1
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| 刊名 | PSYCHIATRIC GENETICS
 |
| 出版日期 | 2014-12-01 |
| 卷号 | 24期号:6页码:257-261 |
| 关键词 | association study females post-traumatic stress disorder single-nucleotide polymorphism tryptophan hydroxylase 2 |
| ISSN号 | 0955-8829 |
| 英文摘要 | Genetic factors are important in the development of post-traumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder have not been definitive. This study examined the association between tryptophan hydroxylase 2 (TPH2) rs11178997 genotype, a single-nucleotide polymorphism (SNP) located in the transcriptional control region, and PTSD symptoms. A total of 326 Chinese adults who suffered from the deadly 2008 Wenchuan earthquake and lost their children during the disaster participated in this study. PTSD symptoms were measured with PTSD checklist, and the SNP was successfully genotyped by the MassARRAY system. The results indicated that, although the rs11178997 genotype was not associated with total PTSD symptoms, it could significantly predict severity of PTSD's avoidance symptoms in women. These findings support that TPH2 may play an important functional role in the development of PTSD and contribute to the limited literature regarding the genetic basis and the sex-specific expression of PTSD's symptoms. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000344918900004 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14230]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Chengqi,Wang, Li,Wang, Richu,et al. TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors[J]. PSYCHIATRIC GENETICS,2014,24(6):257-261. |
| APA | Cao, Chengqi,Wang, Li,Wang, Richu,Qing, Yulan,&Zhang, Jianxin.(2014).TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors.PSYCHIATRIC GENETICS,24(6),257-261. |
| MLA | Cao, Chengqi,et al."TPH2 genotype is associated with PTSD's avoidance symptoms in Chinese female earthquake survivors".PSYCHIATRIC GENETICS 24.6(2014):257-261. |
入库方式： OAI收割
来源：心理研究所
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