Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors
文献类型：期刊论文
| 作者 | Hu, L.1,2,3 ; Cai, M. M.1,2; Xiao, P.1,2; Luo, F.3; Iannetti, G. D.4
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| 刊名 | JOURNAL OF NEUROSCIENCE
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| 出版日期 | 2014-08-20 |
| 卷号 | 34期号:34页码:11439-11451 |
| ISSN号 | 0270-6474 |
| 关键词 | A delta-fibers C-fibers evoked potentials first pain nociception second pain |
| 英文摘要 | Intense radiant heat pulses concomitantly activate A delta-and C-fiber skin nociceptors, and elicit a typical double sensation: an initial A delta-related pricking pain is followed by a C-related prolonged burning sensation. It has been repeatedly reported that C-fiber laser-evoked potentials (C-LEPs) become detectable only when the concomitant activation of A delta-fibers is avoided or reduced. Given that the saliency of the eliciting stimulus is a major determinant of LEPs, one explanation for these observations is that the saliency of the C-input is smaller than that of the preceding A delta-input. However, even if the saliency of the C-input is reduced because of the preceding A delta-input, a C-LEP should still be visible even when preceded by an A delta-LEP response. Here we tested this hypothesis by applying advanced signal processing techniques (peak alignment and time-frequency decomposition) to electroencephalographic data collected in two experiments conducted in 34 and 96 healthy participants. We show that, when using optimal stimulus parameters (delivering >80 stimuli within a small skin territory), C-LEPs can be reliably detected in most participants. Importantly, C-LEPs are observed even when preceded by A delta-LEPs, both in average waveforms and single trials. By providing quantitative information about several response properties of C-LEPs (latency jitter, stimulus-response and perception-response functions, dependency on stimulus repetitions and stimulated area), these results define optimal parameters to record C-LEPs simply and reliably. These findings have important clinical implications for assessing small-fiber function in neuropathies and neuropathic pain. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000341312600027 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14249]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 作者单位 | 1.Southwest Univ, Minist Educ, Key Lab Cognit & Personal, Chongqing, Peoples R China 2.Southwest Univ, Sch Psychol, Chongqing, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.UCL, Dept Neurosci Physiol & Pharmacol, London WC1E 6BT, England |
| 推荐引用方式 GB/T 7714 | Hu, L.,Cai, M. M.,Xiao, P.,et al. Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors[J]. JOURNAL OF NEUROSCIENCE,2014,34(34):11439-11451. |
| APA | Hu, L.,Cai, M. M.,Xiao, P.,Luo, F.,&Iannetti, G. D..(2014).Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors.JOURNAL OF NEUROSCIENCE,34(34),11439-11451. |
| MLA | Hu, L.,et al."Human Brain Responses to Concomitant Stimulation of A delta and C Nociceptors".JOURNAL OF NEUROSCIENCE 34.34(2014):11439-11451. |
入库方式： OAI收割
来源：心理研究所
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