Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia
文献类型：期刊论文
| 作者 | Zhou, Yuan1,2 ; Wang, Zheng3; Zuo, Xi-Nian1,2; Zhang, Huiran3; Wang, Yun1; Jiang, Tianzi4,5; Liu, Zhening3
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| 刊名 | SCHIZOPHRENIA RESEARCH
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| 出版日期 | 2014-10-01 |
| 卷号 | 159期号:1页码:80-89 |
| 关键词 | First-episode schizophrenia Amplitude of low-frequency fluctuation Working memory Task-evoked activity Prefrontal cortex Brain-behavior association |
| ISSN号 | 0920-9964 |
| 英文摘要 | Working memory (WM) deficit is an important component of impaired cognition in schizophrenia. However, between-studies inconsistencies as to the specific functional substrate imply that inter-individual variability (IIV) in the WM performance is associated with IIV in brain activity in schizophrenia. To examine the neural substrate of this WM IIV, we studied whether the neural mechanisms that underlie individual differences in WM capacity are the same in schizophrenia patients and healthy people. We correlated the IIV of the task-evoked brain activity and task performance during an n-back WM task with the IIV of the moment-to-moment variability in intrinsic resting-state activity, as measured by the amplitude of low-frequency fluctuations (ALFFs) and further compared this relationship between 17 patients with first-episode schizophrenia (FES) and 18 healthy controls. Between-group comparisons of the correlation patterns indicated aberrant ALFF-WM activation correlations and ALFF-WM performance correlations in the FES patients, but no significant changes were detected in any single measurement of these three characteristics. Specifically, we found increased positive ALFF-WM activation correlations in the bilateral lateral prefrontal cortices, posterior parietal cortices and fusiform gyri in the FES patients. We also observed significant increases in positive ALFF-WM performance correlations in the bilateral ventromedial prefrontal cortices in the FES patients. This hyper-coupling between the ALFF and fMRI measures during a WM task may indicate that it was difficult for the patients to detach themselves from one state to transition to another and suggests that the inefficient cortical function in schizophrenia stems from the intrinsic functional architecture of the brain. (C) 2014 Elsevier B. V. All rights reserved. |
| 收录类别 | SSCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343107400014 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/14183]  |
| 专题 | 心理研究所_中国科学院行为科学重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China 3.Cent S Univ, Inst Mental Hlth, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Yuan,Wang, Zheng,Zuo, Xi-Nian,et al. Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2014,159(1):80-89. |
| APA | Zhou, Yuan.,Wang, Zheng.,Zuo, Xi-Nian.,Zhang, Huiran.,Wang, Yun.,...&Liu, Zhening.(2014).Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia.SCHIZOPHRENIA RESEARCH,159(1),80-89. |
| MLA | Zhou, Yuan,et al."Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia".SCHIZOPHRENIA RESEARCH 159.1(2014):80-89. |
入库方式： OAI收割
来源：心理研究所
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