Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta
文献类型：期刊论文
| 作者 | Li, Fangxu1,2; Yang, Zhilai1; Lu, Yang1,4; Wei, Yan1; Wang, Jinhui1; Yin, Dazhong2; He, Rongqiao1,3 |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2010-12-22 |
| 卷号 | 5期号:12 |
| ISSN号 | 1932-6203 |
| 英文摘要 | The levels of malondialdehyde (MDA) are high in the brain during carbonyl stress, such as following daily activities and sleep deprivation. To examine our hypothesis that MDA is one of the major substances in the brain leading to fatigue, the influences of MDA on brain functions and neuronal encodings in red-eared turtle (Trachemys scripta) were studied. The intrathecal injections of MDA brought about sleep-like EEG and fatigue-like behaviors in a dose-dependent manner. These changes were found associated with the deterioration of encoding action potentials in cortical neurons. In addition, MDA increased the ratio of gamma-aminobutyric acid to glutamate in turtle's brain, as well as the sensitivity of GABAergic neurons to inputs compared to excitatory neurons. Therefore, MDA, as a metabolic product in the brain, may weaken cerebral function during carbonyl stress through breaking the homeostasis between excitatory and inhibitory neurons. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285578000028 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13676]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100080, Peoples R China 2.Hunan Normal Univ, Coll Life Sci, Changsha, Hunan, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Lab Mental Hlth, Beijing 100080, Peoples R China 4.Univ Sci & Technol China, Hefei, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Fangxu,Yang, Zhilai,Lu, Yang,et al. Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta[J]. PLOS ONE,2010,5(12). |
| APA | Li, Fangxu.,Yang, Zhilai.,Lu, Yang.,Wei, Yan.,Wang, Jinhui.,...&He, Rongqiao.(2010).Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta.PLOS ONE,5(12). |
| MLA | Li, Fangxu,et al."Malondialdehyde Suppresses Cerebral Function by Breaking Homeostasis between Excitation and Inhibition in Turtle Trachemys scripta".PLOS ONE 5.12(2010). |
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来源：心理研究所
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