Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts
文献类型：期刊论文
| 作者 | Wang, Zhao-Xin1; Zhang, John X.2; Wu, Qiu-Lin1; Liu, Ning3; Hu, Xiao-Ping4,5; chan, Raymond C. K.6 ; Xiao, Zhuang-Wei1
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| 刊名 | NEUROIMAGE
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| 出版日期 | 2010 |
| 卷号 | 49期号:1页码:971-976 |
| 关键词 | Addiction Heroin Affective processing Emotion Amygdala Visual cortex |
| ISSN号 | 1053-8119 |
| 产权排序 | 6 |
| 通讯作者 | Xiao, Zhuang-Wei |
| 英文摘要 | Long-term exposure to drug may alter the neural system associated with affective processing, as evidenced by both clinical observations and behavioral data documenting dysfunctions in emotional experiences and processing in drug addicts. Although many imaging studies examined neural responses to drug or drug-related cues in addicts, there have been few studies explicitly designed to reveal their neural abnormalities in processing non-drug-related natural affective materials. The present study asked abstinent heroin addicts and normal controls to passively view standardized affective pictures of positive, negative, or neutral valence and compared their brain activities with functional MRI. Compared to normal controls, addicts showed reduced activation in right amygdala in response to the affective pictures, consistent with previous reports of blunted subjective experience for affective stimuli in addicts. Furthermore, in two visual cortical areas BA 19 and 37, while the controls showed greater responses to positive pictures than to negative ones replicating literature findings, the addicts showed the opposite pattern. The results reveal a complex pattern of altered processing of non-drug-related affected materials in addicts showing both heightened and blunted neural responses in different brain regions and for different stimulus valence. The present study highlights the importance of brain imaging research on drug addicts' processing of affective stimuli in understanding disruptions in their emotion circuitry. (C) 2009 Elsevier Inc. All rights reserved. |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272031700097 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13677]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 作者单位 | 1.Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China 2.Shantou Univ, Coll Med, Affiliated Hosp 1, Guangdong Key Lab Med Mol Imaging, Shantou, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming, Peoples R China 4.Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA 5.Emory Univ, Atlanta, GA 30322 USA 6.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhao-Xin,Zhang, John X.,Wu, Qiu-Lin,et al. Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts[J]. NEUROIMAGE,2010,49(1):971-976. |
| APA | Wang, Zhao-Xin.,Zhang, John X..,Wu, Qiu-Lin.,Liu, Ning.,Hu, Xiao-Ping.,...&Xiao, Zhuang-Wei.(2010).Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts.NEUROIMAGE,49(1),971-976. |
| MLA | Wang, Zhao-Xin,et al."Alterations in the processing of no n-drug-related affective stimuli in abstinent heroin addicts".NEUROIMAGE 49.1(2010):971-976. |
入库方式： OAI收割
来源：心理研究所
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