Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro
文献类型：期刊论文
| 作者 | Sui, Feng1; Lin, Na1; Guo, Jian-You2 ; Zhang, Chang-Bin3; Du, Xin-Liang1; Zhao, Bao-Sheng1; Liu, Hong-Bin1; Yang, Na1; Li, Lan-Fang1; Guo, Shu-Ying1
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| 刊名 | JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
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| 出版日期 | 2010 |
| 卷号 | 12期号:1页码:76-87 |
| 通讯作者邮箱 | huohr@yahoo.com.cn |
| 关键词 | cinnamaldehyde TRPV1 TRPM8 DRG capsaicin menthol |
| ISSN号 | 1028-6020 |
| 产权排序 | 2 |
| 通讯作者 | Hai-Ru Huo |
| 英文摘要 | Cinnamaldehyde (1) is a pharmacologically active ingredient isolated from cassia twig (Ramulus Cinnamomi), which is commonly used in herbal remedies to treat fever-related diseases. Both TRPV1 and TRPM8 ion channel proteins are abundantly expressed in sensory neurons, and are assumed to act as a thermosensor, with the former mediating the feeling of warmth and the latter the feeling of cold in the body. Both of them have recently been reported to be involved in thermoregulation. The purpose of this paper is to further uncover the antipyretic mechanisms of 1 by investigating its effects on the mRNA expression levels and functions of both TRPV1 and TRPM8. The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway. In conclusion, the findings in our in vitro studies might account for part of the peripheral molecular mechanisms for the antipyretic action of 1. |
| 学科主题 | 生理心理学/生物心理学 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277569700012 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/13685]  |
| 专题 | 心理研究所_中国科学院心理研究所回溯数据库(1956-2010) |
| 作者单位 | 1.China Acad Chinese Med Sci, Inst Chinese Mat Med, Tang Ctr Herbal Med Res, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Nanjing Univ Chinese Med, Nanjing 210046, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sui, Feng,Lin, Na,Guo, Jian-You,et al. Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2010,12(1):76-87. |
| APA | Sui, Feng.,Lin, Na.,Guo, Jian-You.,Zhang, Chang-Bin.,Du, Xin-Liang.,...&Jiang, Ting-Liang.(2010).Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,12(1),76-87. |
| MLA | Sui, Feng,et al."Cinnamaldehyde up-regulates the mRNA expression level of TRPV1 receptor potential ion channel protein and its function in primary rat DRG neurons in vitro".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 12.1(2010):76-87. |
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来源：心理研究所
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