Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis
文献类型：期刊论文
| 作者 | Zhou, Bo1 ; Yao, Hongxiang2; Wang, Pan1; Zhang, Zengqiang1,3; Zhan, Yafeng4,5; Ma, Jianhua5; Xu, Kaibin4,6; Wang, Luning1; An, Ningyu2; Liu, Yong4,6
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| 刊名 | BIOMED RESEARCH INTERNATIONAL
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| 出版日期 | 2015 |
| 英文摘要 | The purpose of our study was to investigate whether the whole-brain functional connectivity pattern exhibits disease severity-related alterations in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). Resting-state functional magnetic resonance imaging data were acquired in 27 MCI subjects, 35 AD patients, and 27 age-and gender-matched subjects with normal cognition (NC). Interregional functional connectivity was assessed based on a predefined template which parcellated the brain into 90 regions. Altered whole-brain functional connectivity patterns were identified via connectivity comparisons between the AD and NC subjects. Finally, the relationship between functional connectivity strength and cognitive ability according to the mini-mental state examination (MMSE) was evaluated in the MCI and AD groups. Compared with the NC group, the AD group exhibited decreased functional connectivities throughout the brain. The most significantly affected regions included several important nodes of the default mode network and the temporal lobe. Moreover, changes in functional connectivity strength exhibited significant associations with disease severity-related alterations in the AD and MCI groups. The present study provides novel evidence and will facilitate meta-analysis of whole-brain analyses in AD and MCI, which will be critical to better understand the neural basis of AD. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| 关键词[WOS] | RESTING-STATE FMRI ; DEFAULT-MODE NETWORK ; MEDIAL TEMPORAL-LOBE ; DISCONNECTION SYNDROME ; EPISODIC MEMORY ; CORTICAL HUBS ; INDIVIDUALS ; FREQUENCY ; THALAMUS ; CORTEX |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356685000001 |
| 公开日期 | 2015-09-22 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/7918]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Dept Neurol, Beijing 100853, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Sanya 572014, Peoples R China 4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 5.Southern Med Univ, Sch Biomed Engn, Guangzhou 510515, Guangdong, Peoples R China 6.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bo,Yao, Hongxiang,Wang, Pan,et al. Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis[J]. BIOMED RESEARCH INTERNATIONAL,2015. |
| APA | Zhou, Bo.,Yao, Hongxiang.,Wang, Pan.,Zhang, Zengqiang.,Zhan, Yafeng.,...&Zhang, Xi.(2015).Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis.BIOMED RESEARCH INTERNATIONAL. |
| MLA | Zhou, Bo,et al."Aberrant Functional Connectivity Architecture in Alzheimer's Disease and Mild Cognitive Impairment: A Whole-Brain, Data-Driven Analysis".BIOMED RESEARCH INTERNATIONAL (2015). |
入库方式： OAI收割
来源：自动化研究所
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