Tumor border sharpness correlates with HLA-G expression in low-grade gliomas
文献类型：期刊论文
| 作者 | Wang, Yinyan1,2; Fan, Xing1,2; Li, Hongming3; Lin, Zhiguo4; Bao, Hongbo4; Li, Shaowu2; Wang, Lei2,5 ; Jiang, Tianzi3; Fan, Yong3; Jiang, Tao1,2,6
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| 刊名 | JOURNAL OF NEUROIMMUNOLOGY
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| 出版日期 | 2015-05-15 |
| 卷号 | 282页码:1-6 |
| 关键词 | HLA-G Low-grade glioma Sharpness of the tumor border |
| 英文摘要 | Human leukocyte antigen-G (HLA-G) is a tumor microenvironment molecule that is involved in the escape of cancerous tumors from host immune recognition and destruction. This study investigated the potential relationship between HIA-G expression levels and the sharpness of low-grade glioma tumor borders in magnetic resonance images. Preoperative T2-weighted images from 72 patients were retrospectively examined by manually segmenting the hyperintensive tumor areas and subsequently registering them to a standard brain template. Then, the intensity of the voxels inside the tumor border (tumor voxels) was compared with that of the voxels outside the tumor border (paratumor voxels). The radiologic sharpness of a tumor was defined as the mean ratio of the intensity of the tumor voxels to the intensity of the paratumor voxels. Tumors with high HLA-G expression were associated with larger tumors and lower mean hyperintensive contrast. These findings suggest that tumors with blurred boundaries may be those prone to diffuse invasion. Additionally, patients with tumors having high HLA-G expression were less likely to have undergone complete resections. Thus, this study is the first to identify an association between HLA-G expression and the radiologic morphology of the tumor border, and may further our understanding of the role of the MA gene in immune escape in patients with low-grade gliomas. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Immunology ; Neurosciences |
| 研究领域[WOS] | Immunology ; Neurosciences & Neurology |
| 关键词[WOS] | LEUKOCYTE-ANTIGEN-G ; COLORECTAL-CANCER ; ADAPTIVE IMMUNITY ; MOLECULES ; ESCAPE ; CLASSIFICATION ; GLIOBLASTOMA ; PROGNOSIS ; CARCINOMA ; SURVIVAL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355025300001 |
| 公开日期 | 2015-09-22 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/7921]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Capital Med Univ, Beijing Neurosurg Inst, Beijing 100050, Peoples R China 2.Capital Med Univ, Beijing Tiantan Hosp, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China 4.Harbin Med Univ, Affiliated Hosp 1, Dept Neurosurg, Harbin, Peoples R China 5.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China 6.Beijing Inst Brain Disorders, Ctr Brain Tumor, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yinyan,Fan, Xing,Li, Hongming,et al. Tumor border sharpness correlates with HLA-G expression in low-grade gliomas[J]. JOURNAL OF NEUROIMMUNOLOGY,2015,282:1-6. |
| APA | Wang, Yinyan.,Fan, Xing.,Li, Hongming.,Lin, Zhiguo.,Bao, Hongbo.,...&Jiang, Tao.(2015).Tumor border sharpness correlates with HLA-G expression in low-grade gliomas.JOURNAL OF NEUROIMMUNOLOGY,282,1-6. |
| MLA | Wang, Yinyan,et al."Tumor border sharpness correlates with HLA-G expression in low-grade gliomas".JOURNAL OF NEUROIMMUNOLOGY 282(2015):1-6. |
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来源：自动化研究所
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