Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness
文献类型：期刊论文
| 作者 | He, J. H.1; Cui, Y.2,3 ; Song, M.2,3; Yang, Y.1; Dang, Y. Y.1; Jiang, T. Z.2,3,4,5; Xu, R. X.1
|
| 刊名 | ACTA NEUROLOGICA SCANDINAVICA
 |
| 出版日期 | 2015-03-01 |
| 卷号 | 131期号:3页码:145-151 |
| 关键词 | disorders of consciousness thalamus default mode network functional connectivity functional magnetic resonance imaging |
| 英文摘要 | Background - Interactions between the thalamus and the cortex play an important role in consciousness. The thalamus as a homogenous structure is less strongly connected with the default mode network (DMN) in patients with disorders of consciousness (DOC), but the roles of specific thalamic nuclei are not clear. The purpose of this study was to investigate the functional connectivity between individual thalamic nuclei and the DMN in DOC patients. Methods - Nine DOC patients and nine age-matched healthy controls were scanned with functional magnetic resonance imaging (fMRI) at resting state. Data-driven independent component analysis and hypothesis-driven region of interest-based correlation analysis were performed. Results - In comparison with healthy controls, DOC patients had significantly decreased functional connectivity between the mediodorsal thalamus and brain areas within the DMN, including the medial prefrontal cortex and posterior cingulate cortex/precuneus. Patients and controls did not show significant differences in functional connectivity in other thalamic nuclei. Conclusion - Our results suggest that functional connections between the mediodorsal thalamus and the DMN may play important roles in the pathogenesis of DOC. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Clinical Neurology |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | MONKEY RETROSPLENIAL CORTEX ; PREFRONTAL CORTEX ; BRAIN ; ORGANIZATION ; DISEASE ; LEVEL ; STATE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351164300001 |
| 公开日期 | 2015-09-22 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/8088]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Beijing Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab NeuroInformat, Chengdu 610054, Peoples R China 5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia |
| 推荐引用方式 GB/T 7714 | He, J. H.,Cui, Y.,Song, M.,et al. Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness[J]. ACTA NEUROLOGICA SCANDINAVICA,2015,131(3):145-151. |
| APA | He, J. H..,Cui, Y..,Song, M..,Yang, Y..,Dang, Y. Y..,...&Xu, R. X..(2015).Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness.ACTA NEUROLOGICA SCANDINAVICA,131(3),145-151. |
| MLA | He, J. H.,et al."Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness".ACTA NEUROLOGICA SCANDINAVICA 131.3(2015):145-151. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。