Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults
文献类型：期刊论文
| 作者 | Zhang, Peng1,2; Qin, Wen1,2; Wang, Dawei1,2; Liu, Bing3,4 ; Zhang, Yunting1,2; Jiang, Tianzi3,4; Yu, Chunshui1,2
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| 刊名 | Brain Structure & Function
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| 出版日期 | 2015-05-01 |
| 卷号 | 220期号:3页码:1463-1475 |
| 关键词 | PICALM CLU Hippocampus Functional connectivity FMRI SNP |
| 英文摘要 | PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). Investigating the effects of these genetic variants on the resting-state functional connectivity (rsFC) of the hippocampus may provide new insight into AD pathogenesis. We investigated the main effects and interactions of these two genetic variants on hippocampal rsFC in 283 healthy young adults. The hippocampus showed positive rsFC with the default mode network and negative rsFC with the fronto-parietal network. Risk PICALM G-allele carriers showed weaker negative rsFC compared with AA carriers, whereas risk CLU-CC carriers exhibited stronger positive and negative rsFC than T-allele carriers. There existed complex interactions between PICALM and CLU on the negative rsFC of the hippocampus. Moreover, we found an allele-dependent effect of CLU on hippocampal connectivity when an additive genetic model was applied to CLU. Most of these effects remained significant even after controlling for individual ApoE status. Our results suggest that PICALM and CLU risk genotypes exert differential impacts on the hippocampal rsFC in healthy young subjects. The complex interactions between PICALM and CLU should be considered when investigating the impact of these two genetic variants on the brain. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Anatomy & Morphology ; Neurosciences |
| 研究领域[WOS] | Anatomy & Morphology ; Neurosciences & Neurology |
| 关键词[WOS] | CLATHRIN-MEDIATED ENDOCYTOSIS ; RESTING-STATE FMRI ; GENOME-WIDE ASSOCIATION ; DEFAULT-MODE NETWORK ; EPISODIC MEMORY ; RISK VARIANT ; IDENTIFIES VARIANTS ; GENETIC-CONTROL ; IN-VIVO ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000353515200016 |
| 公开日期 | 2015-09-22 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/8110]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 作者单位 | 1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Peng,Qin, Wen,Wang, Dawei,et al. Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults[J]. Brain Structure & Function,2015,220(3):1463-1475. |
| APA | Zhang, Peng.,Qin, Wen.,Wang, Dawei.,Liu, Bing.,Zhang, Yunting.,...&Yu, Chunshui.(2015).Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.Brain Structure & Function,220(3),1463-1475. |
| MLA | Zhang, Peng,et al."Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults".Brain Structure & Function 220.3(2015):1463-1475. |
入库方式： OAI收割
来源：自动化研究所
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