Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles
文献类型：期刊论文
| 作者 | Cao, Xin1,2; Chen, Xueli1,2; Kang, Fei3; Zhan, Yonghua1,2; Cao, Xu1,2; Wang, Jing3; Liang, Jimin1,2; Tian, Jie1,2,4
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| 刊名 | ACS APPLIED MATERIALS & INTERFACES
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| 出版日期 | 2015-06-10 |
| 卷号 | 7期号:22页码:11775-11782 |
| 关键词 | biophotonics imaging Cerenkov luminescence radioluminescence biomaterials |
| 英文摘要 | Weak intensity and poor penetration depth are two big obstacles toward clinical use of Cerenkov luminescence imaging (CLI). In this proof-of-concept study, we overcame these limitations by using lanthanides-based radioluminescent microparticles (RLMPs), called terbium doped Gd2O2S. The characterization experiment showed that the emission excited by Cerenkov luminescence can be neglected whereas the spectrum experiment demonstrated that the RLMPs can actually be excited by gamma-rays. A series of in vitro experiments demonstrated that RLMPs significantly improve the intensity and the penetration capacity of CLI, which has been extended to as deep as 15 mm. In vivo pseudotumor study further prove the huge potential of this enhancement strategy for Cerenkov luminescence imaging in living animal studies. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | STATE LIGHTING APPLICATIONS ; WHITE EMISSION ; NANOPHOSPHORS ; PROBES ; TOMOGRAPHY ; CONVERSION ; RADIATION ; PET ; FEASIBILITY ; F-18-FDG |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356316700010 |
| 公开日期 | 2015-09-22 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/7910]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Xidian Univ, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China 2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China 3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China 4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Xin,Chen, Xueli,Kang, Fei,et al. Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(22):11775-11782. |
| APA | Cao, Xin.,Chen, Xueli.,Kang, Fei.,Zhan, Yonghua.,Cao, Xu.,...&Tian, Jie.(2015).Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles.ACS APPLIED MATERIALS & INTERFACES,7(22),11775-11782. |
| MLA | Cao, Xin,et al."Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles".ACS APPLIED MATERIALS & INTERFACES 7.22(2015):11775-11782. |
入库方式： OAI收割
来源：自动化研究所
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