In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
文献类型：期刊论文
| 作者 | Hu, Zhenhua1,2 ; Qu, Yawei3; Wang, Kun1,2; Zhang, Xiaojun4; Zha, Jiali3; Song, Tianming1; Bao, Chengpeng1; Liu, Haixiao1; Wang, Zhongliang5; Wang, Jing6
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| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 6 |
| 英文摘要 | Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts g and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | CERENKOV LUMINESCENCE TOMOGRAPHY ; F-18-FDG PET ; NANOPHOSPHORS ; RADIOTRACERS ; FEASIBILITY ; GENERATION ; PROBES ; MODEL |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000357180700001 |
| 公开日期 | 2015-09-22 |
| 源URL | [http://ir.ia.ac.cn/handle/173211/7911]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Gen Hosp Chinese Peoples Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China 5.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 6.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China 7.150 Cent Hosp PLA, Anal Colorectal Surg Inst, Luoyang 471031, Peoples R China 8.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Hu, Zhenhua,Qu, Yawei,Wang, Kun,et al. In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging[J]. NATURE COMMUNICATIONS,2015,6. |
| APA | Hu, Zhenhua.,Qu, Yawei.,Wang, Kun.,Zhang, Xiaojun.,Zha, Jiali.,...&Tian, Jie.(2015).In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.NATURE COMMUNICATIONS,6. |
| MLA | Hu, Zhenhua,et al."In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging".NATURE COMMUNICATIONS 6(2015). |
入库方式： OAI收割
来源：自动化研究所
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