Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension
文献类型：期刊论文
| 作者 | He XC; Lin M ; Sha BY; Feng SS; Shi XH(施兴华); Qu ZG; Xu F
|
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015-08-03 |
| 卷号 | 5页码:12808 |
| 通讯作者邮箱 | zgqu@mail.xjtu.edu.cn ; fengxu@mail.xjtu.edu.cn |
| ISSN号 | 2045-2322 |
| 产权排序 | [He, XiaoCong; Qu, ZhiGuo] Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China; [He, XiaoCong; Lin, Min; Sha, BaoYong; Feng, ShangSheng; Qu, ZhiGuo; Xu, Feng] Xi An Jiao Tong Univ, BEBC, Xian 710049, Peoples R China; [Lin, Min; Xu, Feng] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China; [Sha, BaoYong] Xian Med Univ, Inst Basic Med Sci, Xian 710021, Peoples R China; [Shi, XingHua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100864, Peoples R China |
| 通讯作者 | Qu, ZG (reprint author), Xi An Jiao Tong Univ, Sch Energy & Power Engn, Minist Educ, Key Lab Thermofluid Sci & Engn, Xian 710049, Peoples R China. |
| 中文摘要 | Understanding interactions between cell-penetrating peptides and biomembrane under tension can help improve drug delivery and elucidate mechanisms underlying fundamental cellular events. As far as the effect of membrane tension on translocation, it is generally thought that tension should disorder the membrane structure and weaken its strength, thereby facilitating penetration. However, our coarse-grained molecular dynamics simulation results showed that membrane tension can restrain polyarginine translocation across the asymmetric membrane and that this effect increases with increasing membrane tension. We also analyzed the structural properties and lipid topology of the tensed membrane to explain the phenomena. Simulation results provide important molecular information on the potential translocation mechanism of peptides across the asymmetric membrane under tension as well as new insights in drug and gene delivery. |
| 学科主题 | Science & Technology - Other Topics |
| 分类号 | 一类 |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 收录类别 | SCI |
| 原文出处 | http://dx.doi.org/10.1038/srep12808 |
| 语种 | 英语 |
| WOS记录号 | WOS:000358853400001 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/55326]  |
| 专题 | 力学研究所_非线性力学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | He XC,Lin M,Sha BY,et al. Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension[J]. SCIENTIFIC REPORTS,2015,5:12808. |
| APA | He XC.,Lin M.,Sha BY.,Feng SS.,Shi XH.,...&Xu F.(2015).Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension.SCIENTIFIC REPORTS,5,12808. |
| MLA | He XC,et al."Coarse-grained molecular dynamics studies of the translocation mechanism of polyarginines across asymmetric membrane under tension".SCIENTIFIC REPORTS 5(2015):12808. |
入库方式： OAI收割
来源：力学研究所
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