Detection of urinary drug metabolite (Xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy
文献类型：期刊论文
| 作者 | Holmes, Elaine; Loo, Ruey Leng; Cloarec, Olivier; Coen, Muireann; Tang, Huiru; Maibaum, Elaine; Bruce, Stephen; Chan, Queenie; Elliott, Paul; Stamler, Jeremiah |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2007-04-01 |
| 卷号 | 79期号:7页码:2629-2640 |
| 英文摘要 | Western populations use prescription and nonprescription drugs extensively, but large-scale population usage is rarely assessed objectively in epidemiological studies. Here we apply statistical methods to characterize structural pathway connectivities of metabolites of commonly used drugs detected routinely in H-1 NMR spectra of urine in a human population study. H-1 NMR spectra were measured for two groups of urine samples obtained from U.S. participants in a known population study. The novel application of a statistical total correlation spectroscopy (STOCSY) approach enabled rapid identification of the major and certain minor drug metabolites in common use in the population, in particular, from acetaminophen and ibuprofen metabolites. This work shows that statistical connectivities between drug metabolites can be established in routine "high-throughput" NMR screening of human samples from participants who have randomly self-administered drugs. This approach should be of value in considering interpopulation patterns of drug metabolism in epidemiological and pharmacogenetic studies. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Analytical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | PERFORMANCE LIQUID-CHROMATOGRAPHY ; MAGNETIC-RESONANCE-SPECTROSCOPY ; BLOOD-PRESSURE ; HPLC-NMR ; ACETAMINOPHEN METABOLITES ; H-1-NMR SPECTROSCOPY ; MASS-SPECTROMETRY ; DIETARY FACTORS ; GUT MICROBIOTA ; DATA SETS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000245304300001 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/7936]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ London Imperial Coll Sci Technol & Med, Div Surg Oncol Reprod Biol & Anaesthet SORA, Fac Med, London SW7 2AZ, England 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan Magnet Resonance Ctr, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 3.Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Publ Hlth, London, England 4.Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA 5.AstraZeneca, Dept Drug Metab & Pharmacokinet, Macclesfield, Cheshire, England |
| 推荐引用方式 GB/T 7714 | Holmes, Elaine,Loo, Ruey Leng,Cloarec, Olivier,et al. Detection of urinary drug metabolite (Xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy[J]. ANALYTICAL CHEMISTRY,2007,79(7):2629-2640. |
| APA | Holmes, Elaine.,Loo, Ruey Leng.,Cloarec, Olivier.,Coen, Muireann.,Tang, Huiru.,...&Nicholson, Jeremy K..(2007).Detection of urinary drug metabolite (Xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy.ANALYTICAL CHEMISTRY,79(7),2629-2640. |
| MLA | Holmes, Elaine,et al."Detection of urinary drug metabolite (Xenometabolome) signatures in molecular epidemiology studies via statistical total correlation (NMR) spectroscopy".ANALYTICAL CHEMISTRY 79.7(2007):2629-2640. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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