MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve
文献类型：期刊论文
| 作者 | Wu, Qizhu; Butzkueven, Helmut; Gresle, Melissa; Kirchhoff, Frank; Friedhuber, Anna; Yang, Qing; Wang, Hong; Fang, Ke; Lei, Hao; Egan, Gary F. |
| 刊名 | NEUROIMAGE
 |
| 出版日期 | 2007-10-01 |
| 卷号 | 37期号:4页码:1138-1147 |
| 关键词 | MRI diffusion weighted imaging principal diffusivities axonal injury optic neuritis |
| 英文摘要 | Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) are widely used to investigate central nervous system (CNS) white matter structure and pathology. Changes in principal diffusivities parallel and perpendicular to nerve fibers or axonal tracts have been associated with axonal pathology and de/dysmyelination respectively. However, the ultra-structural properties and the pathological alterations of white matter responsible for diffusivity changes have not been fully elucidated. We examined the relationship between the directional diffusivities and ultra-structural properties in mouse optic nerve using healthy animals, and mice with optic neuritis (ON) that exhibited marked inflammatory changes and moderately severe axonal pathology. Progressive axonal degeneration in ON resulted in a 23% reduction of parallel diffusivity as detected by diffusion MRI (p< 10(-5)), but no change in perpendicular diffusivity. Parallel diffusion changes were highly correlated with the total axolemmal cross-sectional area in the pre-chiasmal portion of the optic nerve (r=0.86, P<0.001). This study provides quantitative evidence that reduced parallel diffusivity in the optic nerve correlates significantly with axolemmal cross-sectional area reductions. MRI-based assessment of axonal degeneration in murine ON is feasible and potentially useful for monitoring of neuroprotective therapies in preclinical trials in animals. (c) 2007 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; ANISOTROPIC WATER DIFFUSION ; RAT SPINAL-CORD ; MULTIPLE-SCLEROSIS ; CORPUS-CALLOSUM ; TENSOR MRI ; DEMYELINATION ; INJURY ; DISABILITY ; LESIONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000249773600019 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/7950]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ Melbourne, Howard Florey Inst, Melbourne, Vic 3010, Australia 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Univ Melbourne, Ctr Neurosci, Parkville, Vic 3052, Australia 4.Univ Melbourne, Fac Med Dent & Hlth Sci, Dept Pathol, Parkville, Vic 3052, Australia 5.Max Planck Inst Expt Med, Dept Neurogenet, Gottingen, Germany 6.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Qizhu,Butzkueven, Helmut,Gresle, Melissa,et al. MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve[J]. NEUROIMAGE,2007,37(4):1138-1147. |
| APA | Wu, Qizhu.,Butzkueven, Helmut.,Gresle, Melissa.,Kirchhoff, Frank.,Friedhuber, Anna.,...&Kilpatrick, Trevor J..(2007).MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve.NEUROIMAGE,37(4),1138-1147. |
| MLA | Wu, Qizhu,et al."MR diffusion changes correlate with ultra-structurally defined axonal degeneration in murine optic nerve".NEUROIMAGE 37.4(2007):1138-1147. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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