Progressive atrophy in the optic pathway and visual cortex of early blind Chinese adults: A voxel-based morphometry magnetic resonance imaging study
文献类型：期刊论文
| 作者 | Pan, Wen-Ju; Wu, Guangyao; Li, Chun-Xia; Lin, Fuchun; Sun, Junmo; Lei, Hao |
| 刊名 | NEUROIMAGE
 |
| 出版日期 | 2007-08-01 |
| 卷号 | 37期号:1页码:212-220 |
| 关键词 | blindness magnetic resonance imaging voxel-based morphometry visual cortex atrophy |
| 英文摘要 | Many previous neuroimaging studies have shown that the early visual cortex of the early blind (EB) exhibits significant functional plasticity. However, only few previous studies have addressed the question whether or not such functional plasticity is accompanied by, and even related to, structural plasticity. In this study, we acquired high-resolution whole-brain anatomical magnetic resonance images form 14 Chinese EB adults, who lost sight before 6 years of age, and 16 age/gender-matched normal-sighted controls (SC), and compared pixel-by-pixel the gray matter (GM) and white matter (WM) volumes between the two groups with voxel-based morphometry. The results showed that, relative to the SC, the EB exhibits significantly reduced WM volumes in the optic tract and optic radiation and significant GM losses in the early visual cortex. The reduction of WM volume in the optic radiation of the EB was found be modulated by both the age at blindness onset and the duration of blindness. The reduction of GM volume in the early visual cortex of the EB appeared to be unaffected by the age at blindness onset. However, it was found in localized regions of the atrophic early visual cortex of the EB that the GM loss was progressive with aging and increasing duration of blindness. These results suggest that early visual deprivation induces significant structural plasticity in the optic pathway and early visual cortex of the EB, which likely occurs during both the critical period of early neurodevelopment and the course of persisted blindness later in life through activity-dependent mechanisms. (c) 2007 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | CROSS-MODAL PLASTICITY ; CONGENITALLY BLIND ; WHITE-MATTER ; SIGHTED INDIVIDUALS ; HUMANS ; ACTIVATION ; BRAIN ; MATURATION ; FMRI ; DISCRIMINATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000248526700020 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/7954]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Wuhan Univ, Zhongnan Hosp, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pan, Wen-Ju,Wu, Guangyao,Li, Chun-Xia,et al. Progressive atrophy in the optic pathway and visual cortex of early blind Chinese adults: A voxel-based morphometry magnetic resonance imaging study[J]. NEUROIMAGE,2007,37(1):212-220. |
| APA | Pan, Wen-Ju,Wu, Guangyao,Li, Chun-Xia,Lin, Fuchun,Sun, Junmo,&Lei, Hao.(2007).Progressive atrophy in the optic pathway and visual cortex of early blind Chinese adults: A voxel-based morphometry magnetic resonance imaging study.NEUROIMAGE,37(1),212-220. |
| MLA | Pan, Wen-Ju,et al."Progressive atrophy in the optic pathway and visual cortex of early blind Chinese adults: A voxel-based morphometry magnetic resonance imaging study".NEUROIMAGE 37.1(2007):212-220. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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