Synthesis and evaluation of Gd-DTPA-labeled arabinogalactans as potential MRI contrast agents
文献类型：期刊论文
| 作者 | Li, Weisheng1,2; Li, Zhongfeng1,2; Jing, Fengying1; Deng, Yuefeng1; Wei, Lai1,2; Liao, Peiqiu1,2; Yang, Xiangguang1; Li, Xiaojing1; Pei, Fengkui1; Wang, Xuxia2,3 |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2008-03-17 |
| 卷号 | 343期号:4页码:685-694 |
| 关键词 | magnetic resonance imaging contrast agent liver-specific arabinogalactan relaxivity |
| 英文摘要 | Arabinogalactan derivatives conjugated with gad olinium-diethylenetriaminepentaacetic acid (Gd-DTPA) by ethylenediamine (Gd-DTPA-CMAG-A(2)) or hexylamine (Gd-DTPA-CMAG-A(6)) have been synthesized and characterized by means of Fourier transform infrared spectra (FTIR), C-13 nuclear magnetic resonance (C-13 NMR), size exclusion chromatography (SEC), and inductively coupled plasma atomic emission spectrometry (ICP-AES). Relaxivity studies showed that arabinogalactan-bound complexes possessed higher relaxation effectiveness compared with the clinically used Gd-DTPA, and the influence of the spacer arm lengths on the T-1 relaxivities was studied. Their stability was investigated by competition study with Ca2+, EDTA, and DTPA. MR imaging of Wistar rats showed remarkable enhancement in rat liver and kidney after i.v. injection of Gd-DTPA-CMAG-A2 (0.079 +/- 10.002 mmol/kg Gd3+) : The mean percentage enhancement of the liver parenchyma and kidney was 38.7 +/- 6.4% and 69.4 +/- 4.4% at 10-30 min. Our preliminary in vivo and in vitro study indicates that the arabinogalactan-bound complexes are potential liver-specific contrast agents for MRI. (c) 2008 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | GD3+-DIETHYLENETRIAMINEPENTAACETIC ACID ; PARAMAGNETIC PROPERTIES ; GADOLINIUM COMPLEXES ; PROTON RELAXATION ; SERUM-ALBUMIN ; PROTEINS ; DEXTRAN ; DERIVATIVES ; CONJUGATE ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000254720800011 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/7967]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 10039, Peoples R China 3.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Weisheng,Li, Zhongfeng,Jing, Fengying,et al. Synthesis and evaluation of Gd-DTPA-labeled arabinogalactans as potential MRI contrast agents[J]. CARBOHYDRATE RESEARCH,2008,343(4):685-694. |
| APA | Li, Weisheng.,Li, Zhongfeng.,Jing, Fengying.,Deng, Yuefeng.,Wei, Lai.,...&Lei, Hao.(2008).Synthesis and evaluation of Gd-DTPA-labeled arabinogalactans as potential MRI contrast agents.CARBOHYDRATE RESEARCH,343(4),685-694. |
| MLA | Li, Weisheng,et al."Synthesis and evaluation of Gd-DTPA-labeled arabinogalactans as potential MRI contrast agents".CARBOHYDRATE RESEARCH 343.4(2008):685-694. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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