Technology Insight: metabonomics in gastroenterology - basic principles and potential clinical applications
文献类型：期刊论文
| 作者 | Bjerrum, Jacob T.; Nielsen, Ole H.3; Wang, Yulan L.1; Olsen, Jorgen2 |
| 刊名 | NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY
 |
| 出版日期 | 2008-06-01 |
| 卷号 | 5期号:6页码:332-343 |
| 关键词 | chemometrics gastroenterology metabonomics nuclear magnetic resonance spectroscopy systems biology |
| 英文摘要 | Metabonomics-the study of metabolic changes in an integrated biologic system-is an emerging field. This discipline joins the other 'omics'(genomics, transcriptomics and proteomics) to give rise to a comprehensive, systems-biology approach to the evaluation of holistic in vivo function. Metabonomics, especially when based on nuclear magnetic resonance spectroscopy, has the potential to identify biomarkers and prognostic factors, enhance clinical diagnosis, and expand hypothesis generation. As a consequence, the use of metabonomics has been extensively explored in the past decade, and applied successfully to the study of human diseases, toxicology, microbes, nutrition, and plant biology. This Review introduces the basic principles of nuclear magnetic resonance spectroscopy and commonly used tools for multivariate data analysis, before considering the applications and future potential of metabonomics in basic and clinical research, with emphasis on applications in the field of gastroenterology. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Gastroenterology & Hepatology |
| 研究领域[WOS] | Gastroenterology & Hepatology |
| 关键词[WOS] | MAGNETIC-RESONANCE-SPECTROSCOPY ; INFLAMMATORY-BOWEL-DISEASE ; SPINNING H-1-NMR SPECTROSCOPY ; CORRELATION NMR-SPECTROSCOPY ; PATTERN-RECOGNITION METHODS ; H-1 MR SPECTROSCOPY ; MULTIVARIATE DATA-ANALYSIS ; ENVIRONMENTAL QSAR DATA ; HUMAN HEPATIC-TUMORS ; HUMAN BRAIN-TUMORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000256352300011 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/7984]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 2.Univ Copenhagen, Panum Inst, Dept Mol & Cellular Med, DK-1168 Copenhagen, Denmark 3.Univ Copenhagen, Herlev Hosp, Med Sect, Gastroenterol Unit, DK-2730 Herlev, Denmark |
| 推荐引用方式 GB/T 7714 | Bjerrum, Jacob T.,Nielsen, Ole H.,Wang, Yulan L.,et al. Technology Insight: metabonomics in gastroenterology - basic principles and potential clinical applications[J]. NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY,2008,5(6):332-343. |
| APA | Bjerrum, Jacob T.,Nielsen, Ole H.,Wang, Yulan L.,&Olsen, Jorgen.(2008).Technology Insight: metabonomics in gastroenterology - basic principles and potential clinical applications.NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY,5(6),332-343. |
| MLA | Bjerrum, Jacob T.,et al."Technology Insight: metabonomics in gastroenterology - basic principles and potential clinical applications".NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY 5.6(2008):332-343. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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