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Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes
文献类型：期刊论文
| 作者 | Claus, Sandrine P.1; Tsang, Tsz M.1; Wang, Yulan2; Cloarec, Olivier1; Skordi, Eleni1; Martin, Francois-Pierre3; Rezzi, Serge3; Ross, Alastair3; Kochhar, Sunil3; Holmes, Elaine1 |
| 刊名 | MOLECULAR SYSTEMS BIOLOGY
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 4 |
| 关键词 | germ-free gut microbiota metabolism metabonomics |
| 英文摘要 | To characterize the impact of gut microbiota on host metabolism, we investigated the multi-compartmental metabolic profiles of a conventional mouse strain (C3H/HeJ) (n=5) and its germfree (GF) equivalent (n=5). We confirm that the microbiome strongly impacts on the metabolism of bile acids through the enterohepatic cycle and gut metabolism (higher levels of phosphocholine and glycine in GF liver and marked higher levels of bile acids in three gut compartments). Furthermore we demonstrate that (1) well-defined metabolic differences exist in all examined compartments between the metabotypes of GF and conventional mice: bacterial co-metabolic products such as hippurate (urine) and 5-aminovalerate (colon epithelium) were found at reduced concentrations, whereas raffinose was only detected in GF colonic profiles. (2) The microbiome also influences kidney homeostasis with elevated levels of key cell volume regulators (betaine, choline, myoinositol and so on) observed in GF kidneys. (3) Gut microbiota modulate metabotype expression at both local (gut) and global (biofluids, kidney, liver) system levels and hence influence the responses to a variety of dietary modulation and drug exposures relevant to personalized health-care investigations. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 研究领域[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | SPINNING H-1-NMR SPECTROSCOPY ; BILE-ACIDS ; GASTROINTESTINAL MICROFLORA ; GLUTATHIONE METABOLISM ; HEPATIC-ENCEPHALOPATHY ; MAGNETIC-RESONANCE ; ORGANIC OSMOLYTES ; ESCHERICHIA-COLI ; HOST ; RATS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260722900001 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8008]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ London Imperial Coll Sci Technol & Med, Dept Biomol Med, SORA Div, London SW7 2AZ, England 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan Ctr Magnet Resonance, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 3.Nestle Res Ctr, BioAnalyt Sci Dept, CH-1000 Lausanne, Switzerland |
| 推荐引用方式 GB/T 7714 | Claus, Sandrine P.,Tsang, Tsz M.,Wang, Yulan,et al. Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes[J]. MOLECULAR SYSTEMS BIOLOGY,2008,4. |
| APA | Claus, Sandrine P..,Tsang, Tsz M..,Wang, Yulan.,Cloarec, Olivier.,Skordi, Eleni.,...&Nicholson, Jeremy K..(2008).Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes.MOLECULAR SYSTEMS BIOLOGY,4. |
| MLA | Claus, Sandrine P.,et al."Systemic multicompartmental effects of the gut microbiome on mouse metabolic phenotypes".MOLECULAR SYSTEMS BIOLOGY 4(2008). |
入库方式： OAI收割
来源：武汉物理与数学研究所
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