Controlled drug release from bifunctionalized mesoporous silica
文献类型：期刊论文
| 作者 | Xu, Wujun1,3; Gao, Qiang1,3; Xu, Yao1; Wu, Dong1; Sun, Yuhan1; Shen, Wanling2,3; Deng, Feng2 |
| 刊名 | JOURNAL OF SOLID STATE CHEMISTRY
 |
| 出版日期 | 2008-10-01 |
| 卷号 | 181期号:10页码:2837-2844 |
| 关键词 | Mesoporous materials Drug release Famotidine |
| 英文摘要 | Serial of trimethylsilyl-carboxyl bifunctionalized SBA-15 (TMS/COOH/SBA-15) have been studied as carriers for controlled release of drug famotidine (Famo). To load Famo with large capacity, SBA-15 with high content of carboxyl groups was successfully synthesized by one-pot synthesis under the assistance of KCl. The mesostructure of carboxyl functionalized SBA-15 (COOH/SBA-15) could still be kept even though the content of carboxyl groups was up to 57.2%. Increasing carboxyl content Could effectively enhance the loading capacity of Famo. Compared with pure SBA-15, into which Famo could be hardly adsorbed, the largest drug loading capacity of COOH/SBA-15 Could achieve 396 9 mg/g The release of.. Famo from mesoporous Silica Was Studied ill simulated intestine fluid (SIF, pH = 7.4). For COOH/SBA-15, the release rate of Famo decreased with narrowing pore size. After grafting TMS groups Oil the Surface of COOH/SBA-15 with hexamethyldisilazane, the release of Famo was greatly delayed with the increasing content of TMS groups. (C) 2008 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Inorganic & Nuclear ; Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | PERFORMANCE LIQUID-CHROMATOGRAPHY ; FUNCTIONALIZED SBA-15 ; DELIVERY RATE ; PORE-SIZE ; FAMOTIDINE ; MCM-41 ; HEXAMETHYLDISILAZANE ; PHARMACOKINETICS ; SILYLATION ; ADSORPTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000260441000042 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8018]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taiyuan 030001, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Wujun,Gao, Qiang,Xu, Yao,et al. Controlled drug release from bifunctionalized mesoporous silica[J]. JOURNAL OF SOLID STATE CHEMISTRY,2008,181(10):2837-2844. |
| APA | Xu, Wujun.,Gao, Qiang.,Xu, Yao.,Wu, Dong.,Sun, Yuhan.,...&Deng, Feng.(2008).Controlled drug release from bifunctionalized mesoporous silica.JOURNAL OF SOLID STATE CHEMISTRY,181(10),2837-2844. |
| MLA | Xu, Wujun,et al."Controlled drug release from bifunctionalized mesoporous silica".JOURNAL OF SOLID STATE CHEMISTRY 181.10(2008):2837-2844. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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