Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3
文献类型：期刊论文
| 作者 | Wang, Yue1; Zhang, Jun-Xia1; Du, Xiao-Xia2; Zhao, Li1; Tian, Qing1; Zhu, Ling-Qiang1; Wang, Shao-Hui1; Wang, Jian-Zhi1 |
| 刊名 | JOURNAL OF NEUROCHEMISTRY
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| 出版日期 | 2008-09-01 |
| 卷号 | 106期号:6页码:2364-2374 |
| 关键词 | acetylcholine Alzheimer's disease correlation glycogen synthase kinase-3 memory tau phosphorylation |
| 英文摘要 | We have reported that activation of glycogen synthase kinase-3 (GSK-3) by ventricle injection of wortmannin (WT) and GF-109203X (GFX) induces Alzheimer-like memory deficit in rats [Liu et al., J. Neurochem. 87 (2003), 1333]. To further explore the factors responsible for the memory loss, we studied here the temporal alterations of GSK-3, tau phosphorylation, beta-amyloid (A beta), and acetylcholine (ACh) after injection of WT/GFX, and analyzed their correlation with the memory loss. We observed that the severe memory deficit occurred at 24 and 48 h, and simultaneously, GSK-3 activation, tau hyper-phosphorylation at Thr231, Ser396, and Ser404 and decline of ACh in hippocampus were detected, and these changes were mostly recovered at 72 and 96 h after the injection of WT/GFX. Remarkable increase of A beta and intracellular accumulation of argentophilic substances were detected at 72 h. Pearson analysis showed that the memory deficit was correlated with GSK-3 activation, tau hyperphosphorylation, and decline of ACh but not with A beta overproduction. Our data provide direct evidence demonstrating that activation of GSK-3 by WT/GFX may cause memory deficit through tau hyperphosphorylation and suppression of ACh in hippocampus. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Neurosciences & Neurology |
| 关键词[WOS] | AMYLOID PRECURSOR PROTEIN ; LONG-TERM POTENTIATION ; MAGNETIC-RESONANCE SPECTROSCOPY ; HELICAL FILAMENT-TAU ; TRANSGENIC MICE ; NEUROFIBRILLARY TANGLES ; SPATIAL MEMORY ; ACETYLCHOLINE-RELEASE ; RAT-BRAIN ; IN-VIVO |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259542000010 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8029]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Pathophysiol, Key Lab Neurol Dis Natl Educ Comm, Wuhan 430030, Peoples R China 2.Chinese Acad Sci, Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yue,Zhang, Jun-Xia,Du, Xiao-Xia,et al. Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3[J]. JOURNAL OF NEUROCHEMISTRY,2008,106(6):2364-2374. |
| APA | Wang, Yue.,Zhang, Jun-Xia.,Du, Xiao-Xia.,Zhao, Li.,Tian, Qing.,...&Wang, Jian-Zhi.(2008).Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3.JOURNAL OF NEUROCHEMISTRY,106(6),2364-2374. |
| MLA | Wang, Yue,et al."Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3".JOURNAL OF NEUROCHEMISTRY 106.6(2008):2364-2374. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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