中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy

文献类型:期刊论文

作者Li, Chun-Xia1,2; Wang, Yaqiang1,2; Gao, Hongchang3; Pan, Wen-Ju1,2; Xiang, Yun1,2,4; Huang, Mingming1,2; Lei, Hao1
刊名NEUROCHEMICAL RESEARCH
出版日期2008-11-01
卷号33期号:11页码:2342-2349
关键词depression chronic forced swimming NMR glutamate metabolism rat
英文摘要Many previous in vivo (1)H magnetic resonance spectroscopy (MRS) studies have shown that patients with major depressive disorder (MDD) are associated with perturbations of cerebral metabolism of neurotransmitters glutamate (Glu) and gamma-aminobutyric acid (GABA). In this study, we investigated the changes of cerebral metabolism in a depression-like rat model of chronic forced swimming stress (CFSS). The aims are to further understand the pathophysiological mechanisms underlying CFSS treatment, and to further establish the face and predictive validity of the CFSS model. The results showed that, relative to control, the CFSS rats had significantly reduced Glu, taurine and glutamate + glutamine (Glx) levels in the PFC, and significantly reduced N-acetyl aspartate (NAA) level, Glu level and Glu/GABA ratio in the hippocampus. Taking together, these results suggest that CFSS treatment can induce region-specific changes in the metabolism of Glu. The CFSS model might be used to study antidepressants specifically targeting the central glutamatergic system.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]GAMMA-AMINOBUTYRIC-ACID ; STRESS-INDUCED CHANGES ; MAJOR DEPRESSION ; PREFRONTAL CORTEX ; ELECTROCONVULSIVE-THERAPY ; HIPPOCAMPAL NEUROGENESIS ; ANTIDEPRESSANT TREATMENT ; GLUTAMATE ; BEHAVIOR ; MEMORY
收录类别SCI
语种英语
WOS记录号WOS:000259483300022
公开日期2015-10-13
源URL[http://ir.wipm.ac.cn/handle/112942/8090]  
专题武汉物理与数学研究所_2011年以前论文发表(包括2011年)
作者单位1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Analyt Chem Lab, Shanghai 201203, Peoples R China
4.Jianghan Univ, Sch Life Sci & Med, Wuhan 430056, Peoples R China
推荐引用方式
GB/T 7714
Li, Chun-Xia,Wang, Yaqiang,Gao, Hongchang,et al. Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy[J]. NEUROCHEMICAL RESEARCH,2008,33(11):2342-2349.
APA Li, Chun-Xia.,Wang, Yaqiang.,Gao, Hongchang.,Pan, Wen-Ju.,Xiang, Yun.,...&Lei, Hao.(2008).Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy.NEUROCHEMICAL RESEARCH,33(11),2342-2349.
MLA Li, Chun-Xia,et al."Cerebral metabolic changes in a depression-like rat model of chronic forced swimming studied by ex vivo high resolution (1)H magnetic resonance spectroscopy".NEUROCHEMICAL RESEARCH 33.11(2008):2342-2349.

入库方式: OAI收割

来源:武汉物理与数学研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。