Accurately probing slow motions on millisecond timescales with a robust NMR relaxation experiment
文献类型：期刊论文
| 作者 | Long, Dong1; Liu, Maili2; Yang, Daiwen1 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2008-02-27 |
| 卷号 | 130期号:8页码:2432-2433 |
| 英文摘要 | A new pulse scheme is proposed for the accurate measurement of relaxation dispersion, which cycles the phases of CPMG pulses. Numerical simulations show that systematic errors in the measured relaxation rates mainly result from off-resonance and radio frequency inhomogeneity effects and they can be significantly suppressed with the method proposed here. The method has been demonstrated on human liver fatty acid binding protein. It allows the reliable identification of residues undergoing conformational exchange on millisecond timescales and accurate extraction of kinetics parameters. The relaxation dispersion data indicate that human liver fatty acid binding protein is highly flexible on millisecond timescales. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | TIME-SCALE DYNAMICS ; DISPERSION EXPERIMENTS ; CAVITY MUTANT ; SIDE-CHAINS ; T4 LYSOZYME ; PROTEINS ; SPECTROSCOPY ; RESIDUES ; EXCHANGE ; SEQUENCE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000253400900030 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8104]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Long, Dong,Liu, Maili,Yang, Daiwen. Accurately probing slow motions on millisecond timescales with a robust NMR relaxation experiment[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2008,130(8):2432-2433. |
| APA | Long, Dong,Liu, Maili,&Yang, Daiwen.(2008).Accurately probing slow motions on millisecond timescales with a robust NMR relaxation experiment.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,130(8),2432-2433. |
| MLA | Long, Dong,et al."Accurately probing slow motions on millisecond timescales with a robust NMR relaxation experiment".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130.8(2008):2432-2433. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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