Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy
文献类型：期刊论文
| 作者 | Liu, Huilang1,3; Fang, Fang1,3; Zhu, Hang1,3; Xia, Sheng-an1,3; Han, Dan2; Hu, Ling2; Lei, Hao1; Liu, Maili1 |
| 刊名 | EXPERIMENTAL NEUROLOGY
 |
| 出版日期 | 2008-08-01 |
| 卷号 | 212期号:2页码:377-385 |
| 关键词 | metabolism hippocampus entorhinal cortex epilepsy early stage HR-MAS H-1 NMR spectroscopy |
| 英文摘要 | The purpose of this study was to determine cerebral metabolic profile changes in response to electric stimulation to the right dorsal hippocampus (HPC) for the establishment of an epileptic rat model. Electroencephalogram measurements and behavioral results indicated that the experimental rats were in an early stage of epilepsy. Metabolites were determined by high-resolution magic-angle-spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy of the following intact brain tissue: bilateral hippocampi, entorhinal cortices (ECs), and temporal lobes (TLs). The NMR data was statistically analyzed using principal component analysis (PCA). Results demonstrated that metabolic profiles were significantly different between the experimental and sham rats in the bilateral hippocampi and the ipsilateral EC. Significant increases in total creatine in the ipsilateral HPC and alanine in the ipsilateral TL were measured (p<0.05). Some metabolite levels were disturbed in the bilateral HPC-EC loops. In the sham group, glutamate and choline concentrations were significantly higher or lower in the ipsilateral EC than bilateral hippocampi, respectively (p<0.01). However, such differences were not observed in the experimental group. In addition, N-acetylaspartate levels in the experimental group were significantly less in the ipsilateral HPC than in bilateral ECs (p<0.05). The level of myo-inositol in the ipsilateral EC significantly increased in the experimental group, compared to the contralateral EC (p<0.05). These results may provide metabolic information about temporal lobe structures to provide more knowledge about epileptic abnormalities at the early stage. (C) 2008 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | SPINNING H-1-NMR SPECTROSCOPY ; MAGNETIC-RESONANCE-SPECTROSCOPY ; ENTORHINAL CORTEX ; PARAHIPPOCAMPAL REGION ; PATTERN-RECOGNITION ; BIOPSY SAMPLES ; SEIZURE ONSET ; 3 T ; EPILEPTOGENESIS ; HIPPOCAMPUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000258252000020 |
| 公开日期 | 2015-10-13 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8115]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan Ctr Magnet Resonance, Wuhan 430071, Peoples R China 2.Wuhan Univ, Coll Med, Dept Physiol, Wuhan 430071, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Huilang,Fang, Fang,Zhu, Hang,et al. Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy[J]. EXPERIMENTAL NEUROLOGY,2008,212(2):377-385. |
| APA | Liu, Huilang.,Fang, Fang.,Zhu, Hang.,Xia, Sheng-an.,Han, Dan.,...&Liu, Maili.(2008).Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy.EXPERIMENTAL NEUROLOGY,212(2),377-385. |
| MLA | Liu, Huilang,et al."Metabolic changes in temporal lobe structures measured by HR-MAS NMR at early stage of electrogenic rat epilepsy".EXPERIMENTAL NEUROLOGY 212.2(2008):377-385. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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