A benzindole substituted carbazole cyanine dye: a novel targeting fluorescent probe for parallel c-myc G-quadruplexes
文献类型：期刊论文
| 作者 | Lin, Dayong1; Fei, Xuening1,2; Gu, Yingchun2,3; Wang, Cuihong2; Tang, Yalin3; Li, Ran2; Zhou, Jianguo2 |
| 刊名 | ANALYST
 |
| 出版日期 | 2015 |
| 卷号 | 140期号:16页码:5772-5780 |
| 英文摘要 | Many organic ligands were synthesized to recognize G-quadruplexes. However, different kinds of G-quadruplexes (G4s) possess different structures and functions. Therefore, selective recognition of certain types of G4s is important for the study of G4s. In this paper, a novel cyanine dye, 3-(2-(4-vinylpyridine))-6-(2-((1-(4-sulfobutyl))-3,3-dimethyl-2-vinylbenz[e]indole)-9-ethyl-carbazole (9E PBIC), composed of benzindole and carbazole was designed and synthesised. The studies on UV-vis and fluorescence properties of the dye with different DNA forms showed that the dye exhibits almost no fluorescence under aqueous buffer conditions, but it increased over 100 fold in the presence of c-myc G4 and 10-30 fold in the presence of other G4s, while little in the presence of single/double-stranded DNA, indicating that it has excellent selectivity to c-myc 2345 G4. For the binding studies the dye is interacted with the c-myc 2345 G-quadruplex by using the end-stack binding model. It can be said that the dye is an excellent targeting fluorescent probe for c-myc G-quadruplexes. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27771]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Tianjin Univ, Sch Environm Sci & Engn, Tianjin 300072, Peoples R China 2.Tianjin Chengjian Univ, Sch Sci, Tianjin 300384, Peoples R China 3.Chinese Acad Sci ICCAS, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, Dayong,Fei, Xuening,Gu, Yingchun,et al. A benzindole substituted carbazole cyanine dye: a novel targeting fluorescent probe for parallel c-myc G-quadruplexes[J]. ANALYST,2015,140(16):5772-5780. |
| APA | Lin, Dayong.,Fei, Xuening.,Gu, Yingchun.,Wang, Cuihong.,Tang, Yalin.,...&Zhou, Jianguo.(2015).A benzindole substituted carbazole cyanine dye: a novel targeting fluorescent probe for parallel c-myc G-quadruplexes.ANALYST,140(16),5772-5780. |
| MLA | Lin, Dayong,et al."A benzindole substituted carbazole cyanine dye: a novel targeting fluorescent probe for parallel c-myc G-quadruplexes".ANALYST 140.16(2015):5772-5780. |
入库方式： OAI收割
来源：化学研究所
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