In vitro and in vivo drug release behavior and osteogenic potential of a composite scaffold based on poly(epsilon-caprolactone)-block-poly(lactic-co-glycolic acid) and beta-tricalcium phosphate
文献类型：期刊论文
| 作者 | Zhao, Pei1,2; Li, Dawei3; Yang, Fei2; Ma, Yuanzheng3; Wang, Tiantian3; Duan, Shun1; Shen, Hong2; Cai, Qing1; Wu, Decheng2; Yang, Xiaoping1 |
| 刊名 | JOURNAL OF MATERIALS CHEMISTRY B
 |
| 出版日期 | 2015 |
| 卷号 | 3期号:34页码:6885-6896 |
| 英文摘要 | To cure serious bone tuberculosis, a novel long-term drug delivery system was designed and prepared to satisfy the needs of both bone regeneration and antituberculous drug therapy. An antituberculous drug (rifampicin, RFP) was loaded into a porous scaffold, which composed of a newly designed polylactone, poly(epsilon-caprolactone)-block-poly(lactic-co-glycolic acid) (beta-PLGC) copolymer, and beta-tricalcium phosphate (beta-TCP). The releasing results demonstrated that RFP could be steadily released for as long as 12 weeks both in vitro and in vivo. During the in vivo experimental period, the drug concentration in tissues surrounding implants was much higher than that in blood which was still superior to the effective value to kill mycobacterium tuberculosis. MC3T3-E1 osteoblasts proliferated well in extracts and co-cultures on composite scaffolds, indicating good cytocompatibility and cell affinity of the scaffolds. The results of a rabbit radius repair experiment displayed that scaffolds have good bone regeneration capacity. The RFP-loaded beta-PLGC/TCP composite scaffold thus could be envisioned to be a potential and promising substrate in clinical treatment of bone tuberculosis. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27693]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Beijing Univ Chem Technol, Beijing Lab Biomed Mat, Beijing 100029, Peoples R China 2.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China 3.309th Hosp PLA, Dept Orthopaed, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Pei,Li, Dawei,Yang, Fei,et al. In vitro and in vivo drug release behavior and osteogenic potential of a composite scaffold based on poly(epsilon-caprolactone)-block-poly(lactic-co-glycolic acid) and beta-tricalcium phosphate[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(34):6885-6896. |
| APA | Zhao, Pei.,Li, Dawei.,Yang, Fei.,Ma, Yuanzheng.,Wang, Tiantian.,...&Wang, Shenguo.(2015).In vitro and in vivo drug release behavior and osteogenic potential of a composite scaffold based on poly(epsilon-caprolactone)-block-poly(lactic-co-glycolic acid) and beta-tricalcium phosphate.JOURNAL OF MATERIALS CHEMISTRY B,3(34),6885-6896. |
| MLA | Zhao, Pei,et al."In vitro and in vivo drug release behavior and osteogenic potential of a composite scaffold based on poly(epsilon-caprolactone)-block-poly(lactic-co-glycolic acid) and beta-tricalcium phosphate".JOURNAL OF MATERIALS CHEMISTRY B 3.34(2015):6885-6896. |
入库方式： OAI收割
来源：化学研究所
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