Supramolecular Hydrogels as Carriers for Sustained Insulin Release
文献类型：期刊论文
| 作者 | Sun, Li-long1,2; Xu, Yun-hua1; Zhu, Wen2; Peng, Bo3; Chen, Yong-ming2,3; Bai, Ru4 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2015-06-20 |
| 期号 | 6页码:673-678 |
| 关键词 | Block copolymer Cyclodextrin Insulin PEG Supramolecular hydrogels |
| 英文摘要 | The supramolecular inclusion of alpha-cyclodextrin (alpha-CD) and PEG contained block copolymer Pluronic F127 was used to build a supramolecular hydrogel system. The composition and gelation behavior of the system were evaluated. There were two kinds of crosslinks in the hydrogels. One was the microcrystalline structure of packed PEG/alpha-CD inclusion complexes, and the other was the aggregated hydrophobic blocks of Pluronic F127. An optimized gel system with low solid content (17. 7 wt%) and short gelation time (6 similar to 8 min) was established for sustained release of insulin. The structure of alpha-CD and PEG inclusion was characterized by wide-angle X-ray diffraction (XRD). The scanning electron microscopy (SEM) images of the freeze-dried powders of the gels showed a porous structure,because of the high water content of the hydrogels. In vitro insulin release was monitored by UV analysis, and the release was sustained in 65 h with a burst release of 30% in the first 5 h. In vitro cytotoxicity studies showed that the hydrogels (without insulin) had no evident growth inhibition to BEL-7402 cells when the concentration was lower than 109 mg/L. Animal experiment showed that the hydrogel was positive to prolong the in vivo insulin release. These results suggested that the supramolecular hydrogels hold great potential as a sustained delivery system of hydrophilic drugs and proteins, such as insulin. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/27852]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Beijing Jiaotong Univ, Dept Chem, Beijing 100044, Peoples R China 2.Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 3.Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China 4.Shenzhen HighTide Biopharmaceut Ltd, Shenzhen 518057, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Li-long,Xu, Yun-hua,Zhu, Wen,et al. Supramolecular Hydrogels as Carriers for Sustained Insulin Release[J]. ACTA POLYMERICA SINICA,2015(6):673-678. |
| APA | Sun, Li-long,Xu, Yun-hua,Zhu, Wen,Peng, Bo,Chen, Yong-ming,&Bai, Ru.(2015).Supramolecular Hydrogels as Carriers for Sustained Insulin Release.ACTA POLYMERICA SINICA(6),673-678. |
| MLA | Sun, Li-long,et al."Supramolecular Hydrogels as Carriers for Sustained Insulin Release".ACTA POLYMERICA SINICA .6(2015):673-678. |
入库方式： OAI收割
来源：化学研究所
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