Lactose targeting oxaliplatin prodrug loaded micelles for more effective chemotherapy of hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Yang,Lixin ; Xiao,Haihua ; Yan,Lesan ; Wang,Rui ; Huang,Yubin ; Xie,Zhigang ; Jing,Xiabin |
| 刊名 | journal of materials chemistry b
 |
| 出版日期 | 2014 |
| 卷号 | 2期号:15页码:2097-2106 |
| 关键词 | DRUG-DELIVERY BIODEGRADABLE POLYURETHANE NANOPARTICLES CANCER CISPLATIN THERAPY COMBINATION SYSTEMS |
| 通讯作者 | yang,lx |
| 英文摘要 | a sugar active targeting system for the platinum(iv) prodrug [oxaliplatin(iv)-cooh or in short form oxapt(iv)] of clinically relevant oxaliplatin (oxapt(ii)) has been reported here for the first time. to achieve this, a series of hydrophilic biocompatible polyurethanes containing free pair-wised pendant amino groups (pu) were synthesized and then lactobionic acid (la) was grafted to the polyurethane as a targeting moiety, in order to prepare pu-la conjugates. thereafter, the prodrug, oxapt(iv) was introduced into the pu-la conjugates resulting in the formation of polyurethane platinum(iv) conjugates (pu-la/pt) with targeting la groups. similarly, pu-pt conjugates without the la targeting groups were also prepared. these conjugates were self-assembled into micelles [non-targeting micelles: m(pu-pt) and targeting micelles: m(pu-la/pt)] in water. an in vitro study demonstrated that, compared with m(pu-pt), m(pu-la/pt) demonstrated a lower ic50 (79 mu m vs. 126 mu m) at 72 h and greater cellular uptake of drugs in hepg2 cells. an in vivo study revealed that m(pu-pt) and m(pu-la/pt) displayed much higher blood drug concentrations and bioavailabilities than the free drug, oxapt(iv). moreover, m(pu-la/pt) showed enriched distribution in the liver and xenograft h22 tumors as well as better antitumor efficacy. m(pu-la/ pt) may be a promising polymeric prodrug of the widely used oxapt(ii) for the clinical treatment of various liver cancers. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000333095000005 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/56215]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yang,Lixin,Xiao,Haihua,Yan,Lesan,et al. Lactose targeting oxaliplatin prodrug loaded micelles for more effective chemotherapy of hepatocellular carcinoma[J]. journal of materials chemistry b,2014,2(15):2097-2106. |
| APA | Yang,Lixin.,Xiao,Haihua.,Yan,Lesan.,Wang,Rui.,Huang,Yubin.,...&Jing,Xiabin.(2014).Lactose targeting oxaliplatin prodrug loaded micelles for more effective chemotherapy of hepatocellular carcinoma.journal of materials chemistry b,2(15),2097-2106. |
| MLA | Yang,Lixin,et al."Lactose targeting oxaliplatin prodrug loaded micelles for more effective chemotherapy of hepatocellular carcinoma".journal of materials chemistry b 2.15(2014):2097-2106. |
入库方式： OAI收割
来源：长春应用化学研究所
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