Efficient Gene Delivery and Multimodal Imaging by Lanthanide-Based Upconversion Nanoparticles
文献类型：期刊论文
| 作者 | Wang, Lin ; Liu, Jianhua ; Dai, Yunlu ; Yang,Qiang ; Zhang,Yuanxin ; Yang,Piaoping ; Cheng,Ziyong ; Lian,Hongzhou ; Li,Chunxia ; Hou,Zhiyao |
| 刊名 | langmuir
 |
| 出版日期 | 2014 |
| 卷号 | 30期号:43页码:13042-13051 |
| 关键词 | RAY COMPUTED-TOMOGRAPHY IN-VIVO DRUG-DELIVERY SIRNA DELIVERY DNA DELIVERY CYTOTOXICITY THERAPY VECTORS POLYETHYLENIMINE CARRIERS |
| 通讯作者 | ma,pa |
| 英文摘要 | nanoparticles have been explored as nonviral gene carriers for years because of the simplicity of surface modification and lack of immune response. lanthanide-based upconversion nanoparticles (ucnps) are becoming attractive candidates for biomedical applications in virtue of their unique optical properties and multimodality imaging ability. here, we report a ucnps-based structure with polyethylenimine coating for both efficient gene transfection and trimodality imaging. cytotoxicity tests demonstrated that the nanoparticles exhibited significantly decreased cytotoxicity compared to polyethylenimine polymer. further, in vitro studies revealed that the gene carriers are able to transfer the enhanced green fluorescence protein (egfp) plasmid dna into hela cells in higher transfection efficiency than pei. gene silencing was also examined by delivering bcl-2 sirna into hela cells, resulting in significant downregulation of target bcl-2 mrna. more importantly, we demonstrated the feasibility of upconversion gene carriers to serve as effective contrast agents for mri/ct/ucl trimodality imaging both in vitro and in vivo. the facile fabrication process, great biocompatibility, enhanced gene transfection efficiency, and great bioimaging ability can make it promising for application in gene therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000343951000038 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/56266]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang, Lin,Liu, Jianhua,Dai, Yunlu,et al. Efficient Gene Delivery and Multimodal Imaging by Lanthanide-Based Upconversion Nanoparticles[J]. langmuir,2014,30(43):13042-13051. |
| APA | Wang, Lin.,Liu, Jianhua.,Dai, Yunlu.,Yang,Qiang.,Zhang,Yuanxin.,...&Hou,Zhiyao.(2014).Efficient Gene Delivery and Multimodal Imaging by Lanthanide-Based Upconversion Nanoparticles.langmuir,30(43),13042-13051. |
| MLA | Wang, Lin,et al."Efficient Gene Delivery and Multimodal Imaging by Lanthanide-Based Upconversion Nanoparticles".langmuir 30.43(2014):13042-13051. |
入库方式： OAI收割
来源：长春应用化学研究所
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