Charge-Conversional PEG-Polypeptide Polyionic Complex Nanoparticles from Simple Blending of a Pair of Oppositely Charged Block Copolymers as an Intelligent Vehicle for Efficient Antitumor Drug Delivery
文献类型：期刊论文
| 作者 | Lv, Shixian ; Song, Wantong ; Tang, Zhaohui ; Li,Mingqiang ; Yu,Haiyang ; Hong,Hua ; Chen,Xuesi |
| 刊名 | molecular pharmaceutics
 |
| 出版日期 | 2014 |
| 卷号 | 11期号:5页码:1562-1574 |
| 关键词 | EXTRACELLULAR PH MICELLES RELEASE INTERNALIZATION DOXORUBICIN CARRIERS VECTORS CANCER |
| 通讯作者 | chen,xs |
| 英文摘要 | a tumor-acidity-activated charge-conversional polyionic complex nanoparticle system was developed by simply mixing a pair of oppositely charged block copolymers: anionic methoxy poly(ethylene glycol)-b-poly(l-glutamic acid-co-l-phenylalanine) (mpeg-b-p(glu-co-phe)) and cationic methoxy poly(ethylene glycol)-b-poly(l-lysine-co-l-phenylalanine) (mpeg-b-p(lys-co-phe)). the nanoparticles could stay negatively charged under normal physiological ph value and reverse the surface charge to positive at the tumor extracellular environment. doxorubicin (dox) was encapsulated into the nanoparticles fabricated by a self-assembly process, and the dox-loaded polyionic complex nanoparticles (dox-nps) retained the charge-conversional property. in vitro dox release study demonstrated that dox release was promoted by the significantly increased acidity in endosomes and lysosomes (ph approximate to 5-6). cellular uptake studies confirmed that the dox-nps could be more effectively internalized by cells at the tumor extracellular ph value. in vitro cytotoxicity assays demonstrated that the polyionic complex nanoparticles had good biocompatibility, and dox-nps showed efficient cell proliferation inhibition to hela and a549 tumor cells. maximum tolerated dose (mtd) studies revealed that dox-nps had a significantly higher mtd (more than 25 mg of dox/kg) in mice compared to that for free dox (5 mg of dox/kg). furthermore, dox-nps showed superior antitumor activity and reduced side toxicity compared to free dox in a549 tumor bearing nude mice. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/56271]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Lv, Shixian,Song, Wantong,Tang, Zhaohui,et al. Charge-Conversional PEG-Polypeptide Polyionic Complex Nanoparticles from Simple Blending of a Pair of Oppositely Charged Block Copolymers as an Intelligent Vehicle for Efficient Antitumor Drug Delivery[J]. molecular pharmaceutics,2014,11(5):1562-1574. |
| APA | Lv, Shixian.,Song, Wantong.,Tang, Zhaohui.,Li,Mingqiang.,Yu,Haiyang.,...&Chen,Xuesi.(2014).Charge-Conversional PEG-Polypeptide Polyionic Complex Nanoparticles from Simple Blending of a Pair of Oppositely Charged Block Copolymers as an Intelligent Vehicle for Efficient Antitumor Drug Delivery.molecular pharmaceutics,11(5),1562-1574. |
| MLA | Lv, Shixian,et al."Charge-Conversional PEG-Polypeptide Polyionic Complex Nanoparticles from Simple Blending of a Pair of Oppositely Charged Block Copolymers as an Intelligent Vehicle for Efficient Antitumor Drug Delivery".molecular pharmaceutics 11.5(2014):1562-1574. |
入库方式： OAI收割
来源：长春应用化学研究所
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