In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction
文献类型：期刊论文
| 作者 | Li, Yangling ; Liu, Chang ; Tan, Ying ; Xu,Kun ; Lu,Cuige ; Wang,Pixin |
| 刊名 | carbohydrate polymers
 |
| 出版日期 | 2014 |
| 卷号 | 110页码:87-94 |
| 关键词 | DRUG-DELIVERY FORMING HYDROGELS MICHAEL ADDITION CLICK CHEMISTRY CHITOSAN DEXTRAN RELEASE NANOSPHERES GELATION VITRO |
| 通讯作者 | tan,y |
| 英文摘要 | polysaccharide-based hydrogels are remarkable materials for the biomedical fields because of its excellent biodegradation and biocompatibility. in this work, a novel polysaccharide-based hydrogel was fabricated by in situ crosslinking of starch-based nanoparticles and polyvinylamine. starch was decorated with cholesterol group and aldehyde groups. tem and dls showed that the cholesterol modified oxidation starch (ocs) exhibited a core-shell nanoparticles with mean size of similar to 143 nm in aqueous. the hydrogel was then synthesized via schiff base reaction. rheological measurements demonstrated the incorporation of cholesterol groups not only reduced the gel time but also improved the storage modulus of the hydrogel compared with the oxide starch crosslinked hydrogel. sem showed the ocs based hydrogels possess a well-defined porous structure. furthermore, doxorubicin (dox) was used as model drug to investigate the control and release properties of ocs hydrogels. this ocs hydrogel would be a promising drug carrier for biomedical applications. (c) 2014 elsevier ltd. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57218]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li, Yangling,Liu, Chang,Tan, Ying,et al. In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction[J]. carbohydrate polymers,2014,110:87-94. |
| APA | Li, Yangling,Liu, Chang,Tan, Ying,Xu,Kun,Lu,Cuige,&Wang,Pixin.(2014).In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction.carbohydrate polymers,110,87-94. |
| MLA | Li, Yangling,et al."In situ hydrogel constructed by starch-based nanoparticles via a Schiff base reaction".carbohydrate polymers 110(2014):87-94. |
入库方式： OAI收割
来源：长春应用化学研究所
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