Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery
文献类型：期刊论文
| 作者 | Gao, Xiaoye ; Cao, Yue ; Song, Xiangfu ; Zhang,Zhe ; Zhuang,Xiuli ; He,Chaoliang ; Chen,Xuesi |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:4页码:565-575 |
| 关键词 | DRUG-DELIVERY COMPLEXATION HYDROGELS ENZYMATIC DEGRADATION SENSITIVE HYDROGEL CELLULOSE CHITOSAN RELEASE NETWORK GROWTH MICROPARTICLES |
| 通讯作者 | he,cl |
| 英文摘要 | biodegradable and ph-responsive carboxymethyl cellulose/poly(acrylic acid) hybrid hydrogels are synthesized. the hydrogels deswell in acidic artificial gastric fluid (agf) but rapidly swell in neutral artificial intestinal fluid (aif), rendering selective enzymatic degradation of the gels as well as accelerated drug release from insulin-loaded hydrogels in aif. oral administration of insulin-loaded hydrogels to streptozotocin-induced diabetic rats leads to a continuous decline in the fasting blood glucose level within 6h post-administration, and the relative pharmacological availability increases more than 10 times compared to oral administration of free insulin solution. the relative bioavailability of hydrogel-encapsulated insulin after oral administration to healthy rabbits is 6.6%. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57241]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Gao, Xiaoye,Cao, Yue,Song, Xiangfu,et al. Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery[J]. macromolecular bioscience,2014,14(4):565-575. |
| APA | Gao, Xiaoye.,Cao, Yue.,Song, Xiangfu.,Zhang,Zhe.,Zhuang,Xiuli.,...&Chen,Xuesi.(2014).Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery.macromolecular bioscience,14(4),565-575. |
| MLA | Gao, Xiaoye,et al."Biodegradable, pH-Responsive Carboxymethyl Cellulose/Poly(Acrylic Acid) Hydrogels for Oral Insulin Delivery".macromolecular bioscience 14.4(2014):565-575. |
入库方式： OAI收割
来源：长春应用化学研究所
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