Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell
文献类型：期刊论文
| 作者 | Ahmad, Zaheer ; Tang, Zhaohui ; Shah, Afzal |
| 刊名 | macromolecular bioscience
 |
| 出版日期 | 2014 |
| 卷号 | 14期号:9页码:1337-1345 |
| 关键词 | INCORPORATED POLYMERIC MICELLES INTRACELLULAR DRUG-DELIVERY BLOCK-COPOLYMER MICELLES CLINICAL-TRIAL SOLID TUMORS IN-VITRO PH OTOTOXICITY DOXORUBICIN RELEASE |
| 通讯作者 | tang,zh |
| 英文摘要 | cisplatin (cis-diaminodichloroplatinum, cddp) loaded methoxy poly (ethylene glycol)-block-poly (glutamic acid-co-phenyl alanine) [mpeg-b-p (glu(10)-co-phe(10)) (pglu(10)) and mpeg-b-p (glu(20)-co-phe(10)) (pglu(20))] nanoparticles with two different formulations (cddp/pglu(10) and cddp/pglu(20)) are successfully developed in uniformly sizes. in 190 h, the cddp/pglu(10) shows 30% release at physiological ph and 39% at lysosomal ph. similarly, the cddp/pglu(20) shows 60% release at physiological ph and 90% release at lysosomal ph. the sustained and controlled release of both formulations evidences the in vitro longevity of the nanoparticles. the cell proliferation inhibition of nanoparticles against human breast cancer cell line zr-75-30 is dose and time dependent. both cddp/pglu(10) and cddp/pglu(20) show excellent hemo compatibility as evaluated by hemolysis experiments. the in vivo fate of cddp and cddp loaded nanoparticles are evaluated by pharmacokinetics studies. free cddp underwgoes instant platinum concentration decrease after intravenous administration with 1.0 wt% left in 24 h while the cddp loaded nanoparticles show prolonged blood circulation time with 5 wt% (cddp/pglu(20)) to 14 wt% (cddp/pglu(10)) left in 24 h. this prolonged blood circulation of cddp loaded nanoparticles makes them as promising nanocarriers for tumor targeting delivery. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-10-27 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/57242]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Ahmad, Zaheer,Tang, Zhaohui,Shah, Afzal. Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell[J]. macromolecular bioscience,2014,14(9):1337-1345. |
| APA | Ahmad, Zaheer,Tang, Zhaohui,&Shah, Afzal.(2014).Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell.macromolecular bioscience,14(9),1337-1345. |
| MLA | Ahmad, Zaheer,et al."Cisplatin Loaded Methoxy Poly (ethylene glycol)-block-Poly (L-glutamic acid-co-L-Phenylalanine) Nanoparticles against Human Breast Cancer Cell".macromolecular bioscience 14.9(2014):1337-1345. |
入库方式： OAI收割
来源：长春应用化学研究所
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